ID A0A0D2DXD1_9EURO Unreviewed; 1505 AA.
AC A0A0D2DXD1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=PV06_00426 {ECO:0000313|EMBL:KIW47763.1};
OS Exophiala oligosperma.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=215243 {ECO:0000313|EMBL:KIW47763.1, ECO:0000313|Proteomes:UP000053342};
RN [1] {ECO:0000313|EMBL:KIW47763.1, ECO:0000313|Proteomes:UP000053342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 72588 {ECO:0000313|EMBL:KIW47763.1,
RC ECO:0000313|Proteomes:UP000053342};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala oligosperma CBS72588.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000256|ARBA:ARBA00008251}.
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DR EMBL; KN847332; KIW47763.1; -; Genomic_DNA.
DR RefSeq; XP_016267979.1; XM_016400926.1.
DR STRING; 215243.A0A0D2DXD1; -.
DR GeneID; 27352500; -.
DR VEuPathDB; FungiDB:PV06_00426; -.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000053342; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 2.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000053342};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1505
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002251807"
FT TRANSMEM 1363..1384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..681
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 715..1352
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1505 AA; 168162 MW; 5CFB9384232360CA CRC64;
MILRSFCRRA VASSLALLLV LSSSQPAQAK KDGPTISSTK FEHALENVFY FDDSDIILAQ
DRDANTIWRS ADAGETWKEV KGGGQSGNAW DLVSHPWDNQ RAYILGLGSE HWITTDQGET
WREFNTNGAS LALFRPSPLS FHGQDAKRVI WNGEQCAGLS CSEVALVTED DFKTVKKMSS
QTRGCQWALG TPEFAEDVAV ELQNRVFCIV EGLYSPWPKD NRLLVSDTFF DEDEIEPALD
HGRAVTGIIS MASVKGFLVA AAKSAGTDEL ALYVTKDGSQ WHRAEFGQHR INEDAYTILE
STNYSMQVDV LDSRPANPIG YLFTSNSNGT YFTRNIDHTN RNIYGRVDFE KVSNIQGIVL
VNVVENFKEV QNSILVEKNI YSQISFDDGR TFQDLKVKDK RLNLHSVTDA KQGGRVFSSP
APGIVMGVGN TGKFLKPYND GDLYVSDDAG VTWYKGLDGA HLYEFGNQGA VIVAVDDEDA
TSHIRYSLDH GKTWKKADLG EKVRVKFLTT LSDSTTLKFS LLGSKGSGSK TEWLIFKIDF
DGLHERTCKE SDFERWPARV DEDGKPTCVM GHKQFYRRRK AEAECFVDEE FKDPVPEFEP
CKCTMADFEC DYNFLRDADD RTKCLPAAPI PVPKGECKGD KDTFKGPSGW RLIPGNECIH
DGGEQLDKEV ERPCSDTSKK PASGDIEIEK TNFDADRFSE WYYLERADKA TGSDETLIMR
TSEQHIFLTH DHGRTWERIL KGEPITAIAP NPNHHDVVFF LTGSKTVHYT IDRGDRFDKF
EAPERPSTLR LPTLRFHPEY KDWLLWSGSV GKDDHTNIFF SKDRGDNWET MVRYARKCEF
ITRESRPDSD QLIYCEQYQD EDPEKALMLL SSENFFGKSE VHFPDILDFA TMSEFIIVAA
KTEDSQGLKV DASVDGHTFA PAEFPKNFQV AHQQAYTVLD SSTHAVFLHV TVNALPDREY
GAIIKSNSNG TSYVFTLDAV NRDTEGYVDF EKMQGLEGVA MTNVVSNLDE VNDGGKKKLK
SMITHNDGAE WTLLPPPKKD ALGNDYKCVK ADNKATDKCS LHIHSYTERS DKSATFSSPS
AVGLMMAVGN VGDRLLRKDD EKTDTFITRD AGITWSSVMK GSYMWEYGDQ GSIIVIVKES
QPTKSLYYTL DEGQSWKEFE FSPNVEMQID AITTVPSDNS LNFLLWGREV GSNAKRGIFT
VAVDFSGLKE RQRPCELDEQ KPENEDYSLW EPKHPMQDSN CLFGHVAQYH RKRTDAQCYN
GKMITHIHNI AQNCSCTRQD FECDYNFQPK ADGTCALVPG FDPPDHAENC RKNPDQVEFW
YPTGYRRIPL TTCQGGQELD KVESKPCKGH EEEYKKKHGI GGAALFFAIT VPLAAAAGIG
YWVYTKWTAG FGGFGQIRLG ESMAASTAPG ESPWISVPVA IVSGIVAVVK ATPLLVISIW
RSAKGYMPVG GGGGGGRFGL GRGASAGYGA PYRSRDAFAR RGQDYSQVVE DDELLGDGLD
DEEDV
//
