ID A0A0D2EI21_9EURO Unreviewed; 1241 AA.
AC A0A0D2EI21;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DOC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV05_06667 {ECO:0000313|EMBL:KIW54300.1};
OS Exophiala xenobiotica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=348802 {ECO:0000313|EMBL:KIW54300.1, ECO:0000313|Proteomes:UP000054342};
RN [1] {ECO:0000313|EMBL:KIW54300.1, ECO:0000313|Proteomes:UP000054342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 118157 {ECO:0000313|EMBL:KIW54300.1,
RC ECO:0000313|Proteomes:UP000054342};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala xenobiotica CBS118157.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the APC10 family.
CC {ECO:0000256|ARBA:ARBA00006762}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family.
CC {ECO:0000256|ARBA:ARBA00006727}.
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DR EMBL; KN847320; KIW54300.1; -; Genomic_DNA.
DR RefSeq; XP_013314884.1; XM_013459430.1.
DR AlphaFoldDB; A0A0D2EI21; -.
DR GeneID; 25328575; -.
DR HOGENOM; CLU_266677_0_0_1; -.
DR OrthoDB; 1386626at2759; -.
DR Proteomes; UP000054342; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd08366; APC10; 1.
DR CDD; cd17352; MFS_MCT_SLC16; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR016901; APC10/Doc1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR012419; Cas1_AcylTrans_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11360; MONOCARBOXYLATE TRANSPORTER; 1.
DR PANTHER; PTHR11360:SF324; TRANSPORTER (MCH2), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12260)-RELATED; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF07779; Cas1_AcylT; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SMART; SM01337; APC10; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000054342};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 528..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 705..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..748
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 847..872
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 892..912
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 941..960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 981..1001
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1028
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1060..1082
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1115..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1139..1165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1208..1228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..342
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 1045..1241
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 40..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1241 AA; 137805 MW; 74BE85322761E400 CRC64;
MPRAPRRAAH HAREAATTTP TRPTATNAIT AAIPPFMLET PPHAPFLTTP LPPSNNPGNS
IVPEANAPRR QQARHQQTPT DHANAHSEGL EHSQVSNNGL GSTVSETGHA EEQSFLESVH
HDVEDAKQLR GLRDISSLAT WTLSSAKPGC ALAQLRNPSP SLFWQSDGPQ PHTLTLHFFK
LVAIVKMRIY LDFELDESYT PTKMKFFAGM SEGGLVEFGS WEVVETPDSE TGETHSSIEG
VRGWIDVPLK GVGGRETLYH EDDDILGNGE SSSYPSQPTS NDAFGGDVLK AMVVQVRICE
NHQNGKDTHV RGFQVFARDH TTPGKVKTRA RKTRHENQAP EDDGELDKVV GLQPADWIQL
FRAIGSTLED QVAMHTSTDI EHYKNSTWAT YSPNLMLIWD PLLAGLMQPR REFVDCDSQA
RCDIEISMTA ARLLHVEQAT PPVLLHNLLN KPYPESFGGT HVRSFPRMLD KWPTTSNPSD
FKMQRPVIST QAQVLLNYIC NDIITVRSKQ SQAYCCVPYT HPHSLQKAFL ITGACIIVSH
LLVSMIQVRL NSSHSLSSRY VVRPTRLILA GATISFAAIY CFAADRTAYF EKSPKGVDQN
MFLCLSATSL LAGLATFKKS SSGPANSETK PYSTPDHQQP LSRGQTEEWK GWMQVAILLY
HYFDMSKVLW VYQFIRVCVA GYLFMTGYGH TMYFLKTNDF SLRRAVNVLL RTNLLNVILA
FVMGTHYDLY YFPALSTVWF LIIWFTIPKK AASHANTWRL MSRIVLSAAI VSLAIRYGEI
METWLTILND VGLGMPVIDG REFLFRFSLD AYVVYFEENS KENGEVAVPI ASGDTVTTYD
PNNEPRYGWV VCGALSTING FTWGILASYG VYLSYYINHA TFPGTSDLDY TFIGGVNFAA
ALISAPLVNL CTQKFGTNVP MYWGSIMFSG GFIAASFATE FWHLVLSQGL LVGLGTGFVW
QPATPVLPQW FNKNRSLAQG IAAAGSGLVG VIFSAATTPM IDHLSLAWSL RITGIISLGA
LVVASILIRD RNTTVRPRIK VFDANLLTQY RVWLLMGYSL FNILGYIVTI YSLSAFAISI
GLSQSQGGIV TTILNLGTAV GRPFVGILSD RFGRMTVVAA LTMVNVVFIY AVWIPTDSFG
LLIFFALVLG VTSGLYWSTI APLCAEVVDL RELPSTLSLM WLTTSLPTLF SEAIALEIRQ
PHSSRPYLWP QIYTGLTYLI SVLFILELRR QKWGWKREKH Q
//
