ID A0A0D2EUD5_9EURO Unreviewed; 567 AA.
AC A0A0D2EUD5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
GN ORFNames=Z517_07690 {ECO:0000313|EMBL:KIW77857.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW77857.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW77857.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW77857.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M.
CC {ECO:0000256|ARBA:ARBA00025513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361124}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
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DR EMBL; KN846973; KIW77857.1; -; Genomic_DNA.
DR RefSeq; XP_013281665.1; XM_013426211.1.
DR AlphaFoldDB; A0A0D2EUD5; -.
DR STRING; 1442368.A0A0D2EUD5; -.
DR GeneID; 25307180; -.
DR VEuPathDB; FungiDB:Z517_07690; -.
DR HOGENOM; CLU_010580_1_0_1; -.
DR OrthoDB; 1343374at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361124}.
FT DOMAIN 11..155
FT /note="Enhancer of polycomb-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10513"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..567
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 64353 MW; 732FD1F68E1A63AA CRC64;
MSTTRGRATR PKKLNSKQNV QIFREDQVDP LSDYDTQRAA IETGVEKAEE SEYHLQQAIK
ASEIAKADAK IKDAYIPTPP TIASDVQYDV LYPRGFQQPA TYIRSSATVE DCAGIAYCMD
EEDELALKLI NGKLPAGQEP CTEDQFEVVM NFFEETAQAK QPFAAVDSPP VLPLEELEEQ
IDDTIPPFVR NLSRFIYEHW KSRRSATGNR PLAPRLKFET GQESDDSDPY VCFRRRELRQ
IRKTRNRDAQ SAEKLRKLRM ELETARNMLL MVKRREQLRK EVLEVDQLVF EQRQALRDTK
RKLGMKGDDD LLINQKKQKI PPGMTPNQAA LAQQLRMPMA SGPGPELRTL EEVANARERE
VQKEIQTNVE KHIRWNEGFV DKTMAPLTPE LEDDYPSPGE HFREAMAATE YLPTPPASIS
DEESQELPNG TDVVMKDVSR PSTPFRYASP ADEDSVGHMP SFRRRIGRGG RIIIDRRLPR
VRRDFTTDDW SKDDRFKFDS DDDDFSDTDP TVPDLTFARM SQRAYLIGAS RPTDAQLLAA
RRSQSEAGGP SHSSPAGQHA QATPAPS
//
