ID A0A0D2F9E6_9EURO Unreviewed; 3181 AA.
AC A0A0D2F9E6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Vacuolar protein sorting-associated protein {ECO:0000256|PIRNR:PIRNR037235};
GN ORFNames=PV04_10336 {ECO:0000313|EMBL:KIW63500.1};
OS Phialophora macrospora.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX NCBI_TaxID=1851006 {ECO:0000313|EMBL:KIW63500.1, ECO:0000313|Proteomes:UP000054266};
RN [1] {ECO:0000313|EMBL:KIW63500.1, ECO:0000313|Proteomes:UP000054266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 27337 {ECO:0000313|EMBL:KIW63500.1,
RC ECO:0000313|Proteomes:UP000054266};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia semiimmersa CBS27337.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. May play a role in mitochondrial lipid
CC homeostasis. {ECO:0000256|PIRNR:PIRNR037235}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545, ECO:0000256|PIRNR:PIRNR037235}.
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DR EMBL; KN846962; KIW63500.1; -; Genomic_DNA.
DR STRING; 5601.A0A0D2F9E6; -.
DR HOGENOM; CLU_000135_0_0_1; -.
DR OrthoDB; 199953at2759; -.
DR Proteomes; UP000054266; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-UniRule.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IEA:UniProtKB-UniRule.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR017148; VPS13_fungi.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR PIRSF; PIRSF037235; VPS13_fungi; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037235};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|PIRNR:PIRNR037235};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037235}.
FT DOMAIN 2..115
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..376
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 597..833
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1950..2526
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2778..2953
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3050..3156
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 417..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1558..1584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1711..1775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 97..134
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 438..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..584
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1383..1403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1737..1775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3181 AA; 357058 MW; 3B98084CF029BEA4 CRC64;
MLEGLVANLL NRFLGMYVKN FDPKQLNVGI WSGDVKLRNL ELRREALDQL RLPINVVEGR
LGELTLSIPW SNLRGKPVRV NIEDVFLLAA PKEEDDYNAE EEEKRAVAVK LEKLESAELL
KEQNTEAMSA EEQQKSQSFT QSFVTAIVDN LQVSIKNVHV RYEDSIATPG HAFAVGLTLK
EMSAVSTDAD WQPTFIQSTS GTTHKLAVLN SLALYWNSDA ELFGTGKGGD VGAEAQEIDK
DELVRRFRQG IEDTAGHQYL LKPVSGRAGI ELDKTGHVDK PKTKARLLFQ ELGFIIDEDQ
YRDALMLVDL MHYFVRHHEY KKDSPKETPK ENPRAWVKFA GQAVLNKIHE RNRKWTWDYF
KERRDTRRKY IELFKKKKKE QQFTEQETKD MAQLEHDLTY EDLRFWRSLA RSQLRRENVG
VKKPPQKQTW SSWVWGSKPE EKQEDDDAGM TDEQRKELYQ AIDWDEKKAL ADAVDLPRET
VKLQVESSLR TGSFTLKRDP HGQSNDILKL VFDNFKLKAL QRPDSFLADV ALGGFRVYDG
TTEGTLFPQI VKVKGAEEQP KEDVKQDDSQ TLDDEDDSEA GTTEKPEEDD SLFHLVFENN
PLDESADTKV DLRLKSLEFI HNPKFVVEIV KFFKPPERQM ESIGALLETA GASIEEIRQQ
TRAGLEFALE EHKTINANLD IHAPILIIPE SITEKSTLCM ILDAGHVSLN SELVDKDTMR
DIHSKQKQKY TEEDHKQLEG LMYDKFHVKL ESTQVLIGPG IEATRAQLEA RVDSQDMHII
DRINMAFLLE NSIIPKAPDV TKIRISGSLP VLHASISDKK YKNLMRLIDV AIPKFDSAEP
EAPEDAVESR PPHAFEDQSA SKRKSVQLLE AKDLPIIEHD SDTEDSPSEE TNQTDTPANI
HQRNFEIKFT VEKLQASLYK ADPDGKKPDQ LLVELVAEHF YFDFYLRPYD MVAEVLLRSL
SVDDHIEKQP LPEFKQIISS KGFKADDGKD LLNVKFVKVN PASPEFISTY EGIATNLDVS
VSTINVVVTR RTLLTLLDFV LTTFASPGGQ QQPIEGKHDE DEPEAIQEAP QQSAPADKIR
IKAELTSIAL ILNNDGVRLA TLSLNSGDVG VFLDAGTIQI KARLGSLSLV DDINEGAPED
SPLRRLIAIE GDDLADFKYQ TFDSTRRDYP GYDSGIYLRS GSIKINFMEE PFRKIMEFGV
KFGRMQAIFN AARQAAADQA QQVQESAQRM HFDVVIKTPI VVFPSVMVDD RPRDVLTAYL
GEIYASNKFV RVQGQKDGPL VNKLTAGIRH IRLTSEFHYD DGSAQELEMI DKVDLTFKIR
YLEHQAGVER PDLEIEGNMS PINLRVSQTQ VKFLTDLSKT IPAAFAMEDE SEEDIAEELP
VSTAESATVS DPNTTTSPAP ATPSYQAPEL GTGDETWTKV NLVFKAPMVS LELMLADEGE
PIESLEAASL SKFAINETSV KMRIMSDGAM EAELVVHSFT IRDSRTKETN KFRKIMSLIN
NDVQQQFMAN VSISGGADRH MIVMLTIDSP RVIVALDYVF ALQAFASTAL QSAEPPPVAE
IEDLTESGEQ SPVEELAEAG DAAGEVESEA KSSMSVSFRV NVVDAQVIFI ANPTISNTEA
IVLGTKEVLL SQQNATTLQI TKIGMFLCRM DRFETSRLRI LDDFSASMSM EKRGQGKDSG
LTSIHIGVEP LVLRLSLRDI LLAMQIVSKA SSTTPQPKMQ EDTEPKKLKD VKASSKAPST
IRKSIAGQST MAQRSKRSKS ISKTTKSSPQ HEQGRQWVVL SREEMIAQID GIRVILIGDM
HELPMLDWSV KKFDVEVHDW SSSLTADTRI DTFINVYNFS KSAWEPLIEP WNLGFHMAKE
LQPEVLSMEL YSHKNMELTV TTATIALASK SFNFLSTDED ILSKPRVADA PYRIRNYTGF
DLSVWADEKS DSAAAAKLTD GEEYAWRFQD TTSMRESLSP EGNAGLVGVK LEGSGFDSVT
RIPVIREGET LYNLKPKKDG VQHRMLVEVA LGTDNVKYIT FRSPLLVENK TQIPIEVGVF
SPEEGHLLKI EKIAPGEARP APVGAAFVHS LVLRPDQGFG YGWSNERLFW KDLLRRPTRT
ITCESEGKDE SPAFFFQMHA SYDEKDPITK VYPYMRIQIS APVEIQNLLP YDFKYRIYDK
NTKKDWTNFL RKGGVSPVHV VELSHLLLLS VDVEDAPFKQ SDFAIINSNT QEEFRREKVV
QLKDERGAQL RLKLHYTNIK NGGGAFRVSV FSPYVLLNKT GLDMSVQSKA FFGSSSKSSS
PHGTRSSAGE GKALPMLYSY GTDDRKNRSL LRIGDSAWSK PQSFDAIGSS YEVVLPAASG
KSELHAGVSV AEGEGKYSLT KVVTIAPRFV LKNKIGEDIE LREPGSSEVW KMQNNELRPV
YFMRQSPEKQ LCLCFPGINN QWSSPFNMDN VGMTHVKLAK HGQRQRLVRV ETILEDATLF
LHFSIETKHW PFSMRNESDT EFLFFQANPN VAEDEEEDKG SGWKPIRYRL PARSIMPYAW
DYPASKNKEL VLIARGKERY VKLAEIGNLI PIKLPPDDRG GPAKAIDVNI VADGPTQTLV
LSNYQPSKSL YRQKTGHTVA SQTSLNQGFE VKQIESEVNF KAELRLAGFG ISLVNSKLKE
LMYITFREME LKYGDSKLYQ TVNFTVKWIQ IDNQLYGGIF PILLYPSVVP KTGKELETHP
IFHAMVTRVK DDSYGVLYIK YATLLLQQIT VELDEDFIFA LLDFVKVPGA SWSEEKEGKL
CDESVDVPEP TREQQGEDVY FELLHLQPIQ LDLSFVRTER VNAEDNFVNS PLMFFVNVMT
MSIGNVNDAP IRFNALLLEN ARISVPALMT NIQNHYTQEA LRQVHIILGS ADFLGNPVGL
FNNISSGVAD IFYEPYQGLV MTDRPQELGI GIAKGASSFV KKSVFGFSDS MAKFSGSISK
GLAAATMDKE FQDQRRMAKN RNRPKHALYG VTAGGSAFAA SMASGIGGLA RHPLEGAEKE
GAFGFVKGVG KGMLGLATKP AIGAFDLASN VAEGVRNTTT VFDAEGLDRV RLTRFIGMDG
IVRPYSQREA LGQFWLKTCN DGQFFNEEYI AHLELEGRDM MVIITYDRIL MLRTKKLRME
WDVKLTDIKT ISKERTGMSI GLKGGANGPF IPVTDEGSRN WLYRQIAIAV NAFNDRYNAK
G
//
