ID A0A0D2F9Q6_9EURO Unreviewed; 1512 AA.
AC A0A0D2F9Q6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000256|ARBA:ARBA00015369};
DE AltName: Full=Carboxypeptidase Y receptor {ECO:0000256|ARBA:ARBA00031354};
DE AltName: Full=Sortilin VPS10 {ECO:0000256|ARBA:ARBA00031250, ECO:0000256|ARBA:ARBA00031902};
GN ORFNames=Z517_02612 {ECO:0000313|EMBL:KIW83367.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW83367.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW83367.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW83367.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC required for the intracellular sorting and delivery of soluble vacuolar
CC proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes
CC multiple rounds of sorting by cycling between the late Golgi and a
CC prevacuolar endosome-like compartment. {ECO:0000256|ARBA:ARBA00025569}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00004488}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004488}.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC {ECO:0000256|ARBA:ARBA00008251}.
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DR EMBL; KN846970; KIW83367.1; -; Genomic_DNA.
DR RefSeq; XP_013287175.1; XM_013431721.1.
DR AlphaFoldDB; A0A0D2F9Q6; -.
DR STRING; 1442368.A0A0D2F9Q6; -.
DR GeneID; 25302102; -.
DR VEuPathDB; FungiDB:Z517_02612; -.
DR HOGENOM; CLU_000700_0_0_1; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 2.
DR Gene3D; 2.10.70.80; -; 2.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1512
FT /note="Vacuolar protein sorting/targeting protein 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002257473"
FT TRANSMEM 1363..1385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..680
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 716..1353
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
SQ SEQUENCE 1512 AA; 169341 MW; 980D91D051E43AAD CRC64;
MIIRSFCRRA VASSVALLLL LTSSPQPTQA KKDGPTISAT TFDNPLENVF YFDDSDVVIG
YDGETGIVWR SADAGETWKE INDQGQSGNA LDVYRHPYDN QRAYIIGLDS DHWVTTDTGE
TWRKFSSDGD GLARFRNAPL SFHGRDPQRV IWNAEHCLGL ACIERAFYTD DDFKTTKRLG
DMTRGCQWAV SAPDFAEELA PEIRDRIFCI VEGLYSPWPK DNRLIVSDDF FQGDQLEPAL
DDGRAVTGII SMAAVKGFLV AAAKSEGTDE LALYVTKDAS QWHRAEFGQH RIDEDAYTIL
ESTNYSLQVD VLGSRPTNPM GYLFTSNSNG TYFTRNIDHT NRNIFGNVDF EKVQSIQGIV
LVNVVDNWKD VEGSTIPRKE IISQISFDDG RTFQDLKVGD KRLHLHSVTD ARQTGRIFSS
PAPGIVMGIG NTGKFLKDYE DGDLFVSDDA GVTWYEGLDG AHLYEFGNQG AVIVAVDDED
STSHIRYSID HGKTWKKAEL PEKVRARFIT TVPDSTTLKF LMMGAKGTGS KTEWVIFKID
FEGLHERACG KDDFERWPAR VDKDGKPSCL MGHKQFFRRR KADAECFIDE EFKDPVPEFE
PCVCTMADFE CDYNFVRDPD DRTKCNPAQP IAVPEGACKS EKDTFKGPSG WRMIPGNECQ
RKGGEELDKE IERPCSDSVK TPASGEITVE KTNFNADRFS EWYYLERSDT SHGNDETIVM
RTSEQDIFLT RDHGKTWEPI LKGEPITAIA PSPYHHDAVF FLTGSKTVHY TIDRGDRFNK
FTAPERPSTL RLPTLRFHPG YKDWLLWSGA VGNDDHTNIW LSKDRGDHWD TLVRYARKCE
FITREGQGQG DQLIYCEQYQ DENPDKNLML LSSDNFFAES KVHFPDILDF ATMSEFIIVA
AKTEDKQSLK VDASVDGRTF APAEFPRNFQ VKHQQAYTVL DSSTHAVFLH VTVNAAQDHE
YGAIIKSNSN GTSYVFTLGG VNRDTEGYVD FEKMQGLEGV AMVNVVSNID ETNNGERKKL
KSMITHNDGA QWAYLPPPKE DALGKNYPCV EEANQATAKC SLHIHSYTER VDKSATFSSP
SAVGLMMAVG NVGEHLLRKD DEATDTFITR DAGITWQSVK KGSYMWEYGD QGSIIVIVKE
SQPTKSLFYT LDEGRTWREF VFSPDVEMQI DAITTVPSDN SRNFLLWGRE VGGNAKRGIF
TVHLDFSGLE ERQVKCELDE KNPEKGDYAL WEPKHPMQAS NCLFGHVAQY HRKRADAKCY
NGKIISHLHN IAKNCSCTRQ DFECDYNYQA QADGTCQLVP GLQPADHEQK CRDNPDQLEF
WYPTGYRRIP LTTCQGGREL DKLESRPCPG HEKEYKKKHG ISGVALFFSI VVPIAASLGI
GYWVYTRWQS GFGSFGQIRL GESMGASGTS SGASSDPLWI KVPVVVLSGV VAVAKAMPLL
VMSLWRSAKG YMPVGSGGSG SGGRFGVGRG SNAGYGAPYR SRDAFARRGQ DYSQVVEDDE
LLGDGLDDEE EV
//
