ID A0A0D2FF36_9EURO Unreviewed; 394 AA.
AC A0A0D2FF36;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Enoyl reductase (ER) domain-containing protein {ECO:0000259|SMART:SM00829};
GN ORFNames=Z517_00647 {ECO:0000313|EMBL:KIW85257.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW85257.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW85257.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW85257.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; KN846969; KIW85257.1; -; Genomic_DNA.
DR RefSeq; XP_013289065.1; XM_013433611.1.
DR AlphaFoldDB; A0A0D2FF36; -.
DR STRING; 1442368.A0A0D2FF36; -.
DR GeneID; 25300137; -.
DR VEuPathDB; FungiDB:Z517_00647; -.
DR HOGENOM; CLU_026673_14_1_1; -.
DR OrthoDB; 2619844at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08278; benzyl_alcohol_DH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43350:SF2; PKS_ER DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 12..391
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 394 AA; 42497 MW; A89322BCFCB6C9E7 CRC64;
MITDAIVVSK PGAPFQYQQL ELHDNLRPDE VLVRIKATGV CRTDLNFSKE KTMPELFPAV
LGHEGAGVVE RKGSNVTRFV KGDHVTVVFS SCGECKYCLR KQTSYCDLWF QYNLGIGRLD
GSKVFSSLST GRPITSHFYG QSSFARHILV SQSGLVKVDR GLSFEMAAAL GCGVMTGAGA
MLNVLDPTPD MTVAVVGVGA VGLSAIMALK MLETPPRKII AVDIVPARLE LARSFGATHG
VNSQVRPELM KVLLDITNGR GVDGAIDTTG KPQVIQELVH SAARKGKVVT VGVEDVCPWT
SSAFIAQADE NSPPKLSAEP SLNVFEMVNA GCTYIGCNQG DCYPPEFLPR LLAAHYEGLF
PYDQLIKTYS AKDIEKAARD VLSGDTVKAV LLWD
//
