ID A0A0D2FGE9_9EURO Unreviewed; 834 AA.
AC A0A0D2FGE9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=ATP-dependent DNA helicase CHL1 {ECO:0000256|ARBA:ARBA00017386};
DE AltName: Full=ATP-dependent DNA helicase chl1 {ECO:0000256|ARBA:ARBA00016387};
DE AltName: Full=Chromosome loss protein 1 {ECO:0000256|ARBA:ARBA00029709};
GN ORFNames=Z518_10118 {ECO:0000313|EMBL:KIX01052.1};
OS Rhinocladiella mackenziei CBS 650.93.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Rhinocladiella.
OX NCBI_TaxID=1442369 {ECO:0000313|EMBL:KIX01052.1, ECO:0000313|Proteomes:UP000053617};
RN [1] {ECO:0000313|EMBL:KIX01052.1, ECO:0000313|Proteomes:UP000053617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 650.93 {ECO:0000313|EMBL:KIX01052.1,
RC ECO:0000313|Proteomes:UP000053617};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Rhinocladiella mackenzie CBS 650.93.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: ATP-dependent DNA helicase important for chromosome
CC transmission and normal cell cycle progression in G(2)/M (By
CC similarity). May have a role in changing DNA topology to allow the
CC loading of proteins involved in maintaining sister chromatid cohesion
CC in the vicinity of the centromeres (By similarity). Has a specific role
CC in chromosome segregation during meiosis II.
CC {ECO:0000256|ARBA:ARBA00025396}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR EMBL; KN847482; KIX01052.1; -; Genomic_DNA.
DR RefSeq; XP_013268188.1; XM_013412734.1.
DR AlphaFoldDB; A0A0D2FGE9; -.
DR STRING; 1442369.A0A0D2FGE9; -.
DR GeneID; 25298189; -.
DR VEuPathDB; FungiDB:Z518_10118; -.
DR HOGENOM; CLU_006515_2_0_1; -.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000053617; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053617}.
FT DOMAIN 4..413
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT COILED 87..114
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 834 AA; 94971 MW; 62293CB8687A1ADB CRC64;
MEPSQADFCH PYQPYSIQLD FMTNLYRCLE EKKVGIFESP TGTGKSLSLI CGALTWLRDH
ERRSLSGTAG ENDPTDWLVQ AESAAQCRGL LLEREELERK LARIREEEAC RRERRVDSRV
LKKARTADAN GADRALDDVE EFMLDDYDDD GEEIPYQRNS TGYSSSTQAL LDKLQQPTKT
DVEEAEKDRL KIIFCSRTHS QLTQFVNELR RVKPPSSIPP GFEDILPDTC LEERIKHLAL
SSRKNLCVNP LVTRLSSTAA INEQCLELQK PRTVKDKRCR YLPSKNDRER VESFRDRAIA
QIRDIEDIGN LGRAMEICPY YASRAAIAST EVLTLPYPLL LQKSAREALG ISLKDNVVVI
DEAHNLMDAI ADTFSMALRL SQLDQAVDQV TAYAMRFKNR LKGKNRVYLT QVIRLLNSLT
DCLRDTMRNT HSTEVSVPAA QLMSGKGVDQ IKPHKLLRYL HESKLCHKVE GYTESQKAEN
ESNHGKGVLM HFQDFLLNLM NPQSEGRFFV SRQDKDIIVR YTLLDPREHF RDIVQDSRAV
ILAGGTMSPM TDYSDYLFSY LEKDRLRTFS FGHVVPASHL FAQAVVNGPS NVEFDFTYEK
RASEKMILEL GHLIVRACRV VPDGVVVFFP SYDYLSQVVS VWQRLPTSQP LMTVLGKTKV
TFQESKFVQV EELLRDYANA VDAGKGGLML SVVGGKLSEG INFSDRLGRA VIAAGLPFPN
ANGAEWKAKM QHIEALRYQQ CKGEGKFKEA ECRTEAKRAS RDFYENACMR AVNQSIGRVI
RHRNDYAAIL MVDRRFATER IRRKLPGWIQ GSMPKGIRAW DEIERSLEDF FQGR
//
