ID A0A0D2FGP0_9EURO Unreviewed; 498 AA.
AC A0A0D2FGP0;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Calcium/proton exchanger {ECO:0000313|EMBL:KIW85847.1};
GN ORFNames=Z517_01239 {ECO:0000313|EMBL:KIW85847.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW85847.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW85847.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW85847.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
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DR EMBL; KN846969; KIW85847.1; -; Genomic_DNA.
DR RefSeq; XP_013289655.1; XM_013434201.1.
DR AlphaFoldDB; A0A0D2FGP0; -.
DR STRING; 1442368.A0A0D2FGP0; -.
DR GeneID; 25300729; -.
DR VEuPathDB; FungiDB:Z517_01239; -.
DR HOGENOM; CLU_008721_1_1_1; -.
DR OrthoDB; 276371at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProt.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR PANTHER; PTHR31503:SF14; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 70..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 173..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 101..279
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 316..457
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 54114 MW; D329EA837CD8DF4F CRC64;
MSAEASSASN TAHQAIGSAD PPSKPHSNNH DSPHSGPGGL LTIHHEGESG RSGIHFWSFL
RILWRSSSQV SMAVNILWPF VPFAIILHYL PGHHSTTLDK WIFAASYIGM VPAANLLGFA
GQELARKMPK VAGILIETAL GSIVEIVLFI ILIAKHKNPE GSGDDSSAEE GNLIPVIQAA
ILGSILTNLL LCLGLCFFFG GIRRQTQTFH AVVSEVGSGL LLVAGFGLLI PSAFYSALKG
ETRPHSGFTE HKLQYDVLKM SQATSIILMI AFAVYIVFNA RSQHGIFDEI LEADEINDED
RTHDLAKKKL TFTECVVAIV VSLTLITLLA VFLVEQIETI VHSGVPDQFL GLILLPLVEK
AAEHLTAVDE AWDGQMNFAL YHCLGPSIQT ALFNGPLVVL VGWALGKPMD LNFEIFMIVL
LVLSILVVGN FLRDKESNYL EGTLLVIVYI IIAIAAWYYP DPDVATSNEF DDPWSVAGFP
PTATSMVSLQ FKTQGTVF
//
