ID A0A0D2FJZ2_9EURO Unreviewed; 921 AA.
AC A0A0D2FJZ2;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Peroxisomal hydratase-dehydrogenase-epimerase {ECO:0000313|EMBL:KIX02297.1};
GN ORFNames=Z518_08237 {ECO:0000313|EMBL:KIX02297.1};
OS Rhinocladiella mackenziei CBS 650.93.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Rhinocladiella.
OX NCBI_TaxID=1442369 {ECO:0000313|EMBL:KIX02297.1, ECO:0000313|Proteomes:UP000053617};
RN [1] {ECO:0000313|EMBL:KIX02297.1, ECO:0000313|Proteomes:UP000053617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 650.93 {ECO:0000313|EMBL:KIX02297.1,
RC ECO:0000313|Proteomes:UP000053617};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Rhinocladiella mackenzie CBS 650.93.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; KN847480; KIX02297.1; -; Genomic_DNA.
DR RefSeq; XP_013269433.1; XM_013413979.1.
DR AlphaFoldDB; A0A0D2FJZ2; -.
DR STRING; 1442369.A0A0D2FJZ2; -.
DR GeneID; 25296308; -.
DR VEuPathDB; FungiDB:Z518_08237; -.
DR HOGENOM; CLU_010194_18_0_1; -.
DR OrthoDB; 2140828at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000053617; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 2.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000053617}.
FT DOMAIN 796..905
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
SQ SEQUENCE 921 AA; 99573 MW; 05F05CF3967D4188 CRC64;
MVQELRFDNQ TVVVTGAGGG LGKAYALFFA SRGANVVVND LGGSFKGEGA GTKVGVFCHM
LLAPVPILTV CIFQAADVVV DEIKAAGGKA VANYDSVEHG EKIIQAAIDT FGRVDVLLNN
AGILRDISFK NMKDSDWDLI NTVHVKGAYK CARAAWPHFR KQKYGRVINT SSAAGLFGSF
GQCNYSAAKL AQVGFTETLA KEGAKYNILC NVIAPIAASR MTETVMPPDV LANLKPEWVV
PLVAVLVHPS NTTENGSIFE VGGGHIAKLR WERAKGLLLK ADHTYTPGAI LKKWDKVSDF
SEPEYPNGVA DMVGKLEESL KMGSNDPGEE IRFDGKVVLV TGGGAGLGRG YCLAFAKLGA
FVVVNDLVNP DTVVQEIQKL GGKAVGNKAS VLDGAAVVKT AIDTFGRIDI LINNAGILRD
KAFVNMDDKL WDDIIAVHLR GTYSVTKAAY PYMLKQKYGR IVNTTSTSGI YGNFGQANYA
AAKLGILGFS RALALEGRKN NIFVNTIAPN AGTQLTRTIL PEELVQAFKP EYVAPLVVLL
CSDRVPEPPT GLLFEVGSGW QARTRWQRSG GHGFPVDVKL TPEHVIEKWS KIIDFKDGRA
DHPENGQEGV KSIMANMANK SKKSDSSGTD YLAAIEKAKQ AKASGTEFSY DDRDVILYNL
SLNAHRTQLP LVYENDDNFQ VLPSFGVIPF FNAESPFSMD EIMPNFSPMM LLHGEQYLEI
RKFPIPTKAR TISYPRLVEV VDKGAACLAV TGITTKDANT GEDLFYNEST VFVRGSGGFG
GPKKGANRGN ATAVYQPPKR APDAVVEEKT SEDQAALYRL NGDRNPLHID PEFSKVGGFK
VPILHGLCFF GFSGKHIVQT YGLFKNIKVR FAGTVLPGQT LVTEMWKEGN KVIFQTKVKE
TGKLCIAGAG AELLGAPKPK L
//
