ID A0A0D2FLT8_9EURO Unreviewed; 2368 AA.
AC A0A0D2FLT8;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Polyketide synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z518_06497 {ECO:0000313|EMBL:KIX02947.1};
OS Rhinocladiella mackenziei CBS 650.93.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Rhinocladiella.
OX NCBI_TaxID=1442369 {ECO:0000313|EMBL:KIX02947.1, ECO:0000313|Proteomes:UP000053617};
RN [1] {ECO:0000313|EMBL:KIX02947.1, ECO:0000313|Proteomes:UP000053617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 650.93 {ECO:0000313|EMBL:KIX02947.1,
RC ECO:0000313|Proteomes:UP000053617};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Rhinocladiella mackenzie CBS 650.93.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN847479; KIX02947.1; -; Genomic_DNA.
DR RefSeq; XP_013270083.1; XM_013414629.1.
DR STRING; 1442369.A0A0D2FLT8; -.
DR GeneID; 25294568; -.
DR VEuPathDB; FungiDB:Z518_06497; -.
DR HOGENOM; CLU_000022_31_0_1; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000053617; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053617};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..434
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2279..2360
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2368 AA; 259606 MW; 527D05919C0C740C CRC64;
MGSLAHDNPV PADIAVIGLA CRFPGGASNT QNFWDLLYQQ KATYADFPRS RDNASTFYQE
GDKINATGSQ KGHFLQQDVS AFDAPFFGIT GQEAKAMHPT ARLLLEVTYE AFENAGLAIE
QLAGSNTSCY VGCSEPDLAG TILYDPESPT TYKTTTSLSL LSSRISWYYD FRGPSLTLDT
GSSSGLVALH LACQALGAGE SKLAVVSGAN LILNIEYATV FANPDRFCQE TSSKSFAGGA
VCHGRGEGVA SILLKPLNDA LRDGDPIRAI IRGTGVNQDG HTIGATVPNS NSPAELIRST
YDSAGLDFSH TVYLEAHGTA RRMGDAFERT AVARSLGYSR KEGRNLLVGS VTSNIGNLEG
ASGLASIVKS ILMLERGIIL PNVHTENTVN PRCSVDLKLA TPTSCIRWPL NSPRRVSVHN
LGSGGTNAHA ILDDATEYLT IRGLQDSSSL SPWVSKNATQ PRLFVFSAHD EAALRRMKKQ
YADYLESYMT TAGSKFQVKE SAFLDQLAFT LSERRSRFDW KTHVVASSIK ELRTQLSSST
VRLGRSSTSN PQVAFVFTGQ SENWARMGVG LFRYPAFKKS ILDADEHLKE AFDCDYSFIE
ELKRDDKGIE THLAAISHPM STVLQVALVD LLRSWNIIPA GVVGHSSGEI GAAYAYGVIS
REDAWTIAYW RSKLCSELTA ESTPPKEAML AVALSKDAVQ EHLSTISHGQ LVIACVNSPS
SVTISGKETA IGQLHEKLSA SSVFCRQLKV PNAFNSHHME QISQRYLEKI STIRPKSPMS
ARNIVMVSSV AGEVIEPRAL APEYWVRNLV SPVKFSDAIE KLFKNKNFDF LLEVGPDSTL
KGPLRQIMRD LNIQNVTYKS IISSGEDAIS SAANSAGMLY TQGFPLCVTA INMIDTRLKP
MTDLPPYPWN HSLKYCIESQ MSSSCPAGGC RRHDILGSVA LGSNELEPKW RNLLRVSEQP
WIQDHVVRGE TIYPAGGIVA MAIESVKQIA NKVESIEKIH LKNVHIPKVI VIPDNEAGIE
CSLQLRRPSS TGSPWTNWWE FSVLSSLDHQ KPEQIAFGLV KVQYKSDDIP SWEIQKTQTV
KMLRGDYQKA KLLCTRRINP KDFYEAEKQA GLNYGPCFQG LTDVSTHSRR CCFKISAPIT
RGSMPGRVES PYTIHPVSIE IMFHSLLAAL GGNIDSNFHT VAIPVSFDSM TVAMELPVGE
NSKFHGHCEA IKEDSGEVVG DVFVSDRSWV EPKVLIRGVH FRKLPPATTP SRPICPWKAP
FGTLAWKPDI HLCQNQSLED YLSQTELVLD LVAHKNPDMS ILQLGGSLSM TRSILSVLAT
DPEDTSRFSN LVAADTNSAI AQDFEDKFRD WGSKLSFIKL NEDLDLQGQT LSPGSFDLII
TGATFSNNMQ KTRFLQDVQG LLKNGGVFLI LESFTDITKT KGWESVVIQS GLQPIGMLQS
DDDEVKSVTT ALCVTVKAYT EVQKKLSDVI YIVQPPNLTE KMSEIGQSVI RRFSSSSMPA
QIVEWPPDPA KLKEQPVISL LELTRPFLIN ISSRDFEMMK TIVQGSSSFL WVSMGSEPMM
TVGMGFFRVL RNENPKLNVR FLLFEEMAGR QPDELAGNIF KVMTSSNPDG EFIQMDGQLC
INRWSPDKGI SRITTDQGGV VLEAMALEES QTPLRIHAEG SGQEQSWYFV AENELSGHPA
PGEVDIVTRA VVLSNQDSTA SSPEPIKEFS GIVKSVHKDC PRFKPGDRVY GCQPAPYRTV
YRVKERFCQQ ILGDDPFEKA ASRPITFGTA YYSLVKIANL QYGQTVLIQA ASTAVGQAGV
QIAQAQVAVV FATVRTEEES LLVEKLGIPR ERILNDADPE LCTTISRLSG RKGFDVILNI
SKDGEDLGDL WRSVASFGHL ISAAAANQLK GPDLDMAPFQ KGCSFAVVDM NLIYRENPTL
MAEISKDLGR YLATSSLRPI EPTRVYSSEQ ISDAFKSTKS QDMSPGTTIV SFNPQDELRI
HPTARNPLHL QKEASYVLVG GLGGFGRHLA RLLVDHGARH MVFLSRSALM AANAQAVVDE
IAARGVITKV FVCDISDETT LSKVVEQCRN EMPPIRGVIQ STAVDNDSLD RKTTHELWLD
ATRIKIRGSW LLHKLLPRKM DFFVLVGSTK RMFGNRTQAS HAAVNTFQHA LAQYRRHQGL
AGAAVDLGPM LGEKFVAEKD GSTNILNLEA PSLSEAELQA IMVAAMTGSY GSNPTPVPLV
TGLPTGGLLH RQGLDGPSYY SDPRFSFLKK MDFGQNVREE ISGEENEESS LAKRLRACQS
LEEASKEICS AMCEFLGEEL QTGAENLEIN SSLYSNGADS LLAVEMRSWL LRQMGAEISL
GDMLSGHSIS ELADKIATAS TLIPAGVK
//
