ID A0A0D2FQK3_9EURO Unreviewed; 1429 AA.
AC A0A0D2FQK3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Dicer-like protein 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV04_10473 {ECO:0000313|EMBL:KIW62289.1};
OS Phialophora macrospora.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX NCBI_TaxID=1851006 {ECO:0000313|EMBL:KIW62289.1, ECO:0000313|Proteomes:UP000054266};
RN [1] {ECO:0000313|EMBL:KIW62289.1, ECO:0000313|Proteomes:UP000054266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 27337 {ECO:0000313|EMBL:KIW62289.1,
RC ECO:0000313|Proteomes:UP000054266};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia semiimmersa CBS27337.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Dicer-like endonuclease involved in cleaving double-stranded
CC RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs
CC (siRNAs) which target the selective destruction of homologous RNAs
CC leading to sequence-specific suppression of gene expression, called
CC post-transcriptional gene silencing (PTGS). Part of a broad host
CC defense response against viral infection and transposons.
CC {ECO:0000256|ARBA:ARBA00025403}.
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR EMBL; KN846963; KIW62289.1; -; Genomic_DNA.
DR STRING; 5601.A0A0D2FQK3; -.
DR HOGENOM; CLU_000907_4_6_1; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000054266; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Antiviral protein {ECO:0000256|ARBA:ARBA00022721};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00657}.
FT DOMAIN 33..212
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 378..539
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 569..664
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 935..1057
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1110..1294
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1408..1429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1429 AA; 160489 MW; 609F7620D5D14224 CRC64;
MDPDSDETWS DTSEEDGSRN APPLQSRAYQ IEMFEHSMMG NIIAVMGTGS GKTQVAKLRI
EAELERSPGK LVWFTAPSVV LAYQQYRFLS QQLPAYQFRL ITGMDNAEYW TSLDIWQKVL
YHIHVVVSTP AILQQALNRG FVVMKGISLL VFDEAHHCVK DSSMNSIMRH HYHPKLTQES
SHELPHILGL SASPITKKKA KEVAELEGNL NAICKSPMQQ LEEYTVFVNM PEPLILAHSP
APTQPSALLD ILTAAVCAVS IEHDPIVAAL RRSKHPHAQE KLEKIQKEQR TPAMEEMQTV
VRSCTELQQS LGTWACDMFI KKCVEKVELM SSRKLDFAAA GALYTDRSAF MASTLQPLLI
PLCMADLDLN TPGSVSSKVT LLVEFLQKGY QSNLRCLIFV KTKVAAWLLT DIINSHPLTQ
GQYCAFSFVG VSNPTRRGIC DFAELSEQHD NLESFRNGEL NVCVATSVLE EGVDIPAMNL
VICFDERPNF RSFIQSRGRA RQRESRFVMF SDTALKTKQW QALEDEMNDE CQKSLESVRQ
REEMEGFSQT DSEVFRIPST GAILTFSEAR QLLDRFCAKL PNKDKSEPMA PIFLLKAEPG
VELRAKVYLP SSLPPSLRIA ESRSSWLTEK KAKQDAAFQA YRALHEAGLV TDLLLPLERP
KEQEVSRDGD ELEKRDSVYD VQKQYDPWPN VMKLWKSPGS CRVYAHRLQL EAPDCFYPSM
LLLLPVRLSK LTFSLFTTKT SIVRVNIGAG VEKQGFPLDI AQDITFLLLT IMLRRRLTGL
RKEQLPSLFV PDIQQSSLQT WYKAASASIP MTDFGQTNSA SCRSYLVQSR RRNVPFLWQP
DAVHGDGQQA CDPQAREGPS SIRATVLPRT LDYSRQVNLP DSVHESVRDL PVDECSVLGL
PSDYGCLVLF IPSIMHMLEV ALRSAAACEG PLTTIGLNNL DLVSEALTLP GASHTRNYER
LEFIGDTILK FYAALHVFAD HPIYPAHHLT RMRGKIINNA RLQRATRLLG LDQYLSRNSF
ATKEWTAGVS GLRPLVKQPS KELSSKTLAD VVEAVIGVAS VSGFEGGVSE EKVLATLKVF
IDEVAWRPLS EIVAQIHTPD RVSEEPADIL APVEVMISYS FQNRGLLAEA LTQSSLAGDS
RSTYDRLEFL GDSILDYIVC PKLFHSPLQL SPGQMTVRRH ALVSHQTLAF FAQKASCTRS
IFRVDTDPRT EKSNVKEEHE TIYLTDYIRQ LGQPQAPRER QATLSAFCAI QPSVLKLLES
GARFPWTLLS RLGAPKSFSD IIESILAAVF IDSKGNLGAC EAVLETIGYM SLVRRFVNER
DIDTRHPEAK LHELIHSQDH RGTVPPLEII TQERKKRGAG DASWRCKVML DDKLIARTKH
ASCADEARYT AVERAVEVLR KKTKREFTEV QKNGPEERHD EMRKKQMAF
//