ID A0A0D2FZ70_9EURO Unreviewed; 1419 AA.
AC A0A0D2FZ70;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Pre-mRNA-splicing factor {ECO:0000256|PIRNR:PIRNR038901};
GN ORFNames=PV04_00026 {ECO:0000313|EMBL:KIW71790.1};
OS Phialophora macrospora.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX NCBI_TaxID=1851006 {ECO:0000313|EMBL:KIW71790.1, ECO:0000313|Proteomes:UP000054266};
RN [1] {ECO:0000313|EMBL:KIW71790.1, ECO:0000313|Proteomes:UP000054266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 27337 {ECO:0000313|EMBL:KIW71790.1,
RC ECO:0000313|Proteomes:UP000054266};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia semiimmersa CBS27337.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in mRNA splicing where it associates with cdc5 and
CC the other cwf proteins as part of the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBUNIT: Belongs to the 40S cdc5-associated complex (or cwf complex), a
CC spliceosome sub-complex reminiscent of a late-stage spliceosome.
CC {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
CC -!- SIMILARITY: Belongs to the CWF11 family.
CC {ECO:0000256|PIRNR:PIRNR038901}.
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DR EMBL; KN846956; KIW71790.1; -; Genomic_DNA.
DR STRING; 5601.A0A0D2FZ70; -.
DR HOGENOM; CLU_001195_0_0_1; -.
DR OrthoDB; 7041at2759; -.
DR Proteomes; UP000054266; Unassembled WGS sequence.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd17935; EEXXQc_AQR; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR048966; Aquarius_b-barrel.
DR InterPro; IPR048967; Aquarius_insert.
DR InterPro; IPR032174; Aquarius_N.
DR InterPro; IPR026300; CWF11_fam.
DR InterPro; IPR045055; DNA2/NAM7-like.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR PANTHER; PTHR10887:SF5; RNA HELICASE AQUARIUS; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF16399; Aquarius_N_1st; 1.
DR Pfam; PF21143; Aquarius_N_2nd; 1.
DR Pfam; PF21144; Aquarius_N_3rd; 1.
DR PIRSF; PIRSF038901; AQR_cwf11; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR038901};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR038901};
KW Nucleus {ECO:0000256|PIRNR:PIRNR038901}.
FT DOMAIN 30..414
FT /note="RNA helicase aquarius N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16399"
FT DOMAIN 494..660
FT /note="RNA helicase aquarius beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF21143"
FT DOMAIN 709..795
FT /note="RNA helicase aquarius insertion"
FT /evidence="ECO:0000259|Pfam:PF21144"
FT DOMAIN 809..1107
FT /note="DNA2/NAM7 helicase helicase"
FT /evidence="ECO:0000259|Pfam:PF13086"
FT DOMAIN 1119..1310
FT /note="DNA2/NAM7 helicase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13087"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1392..1419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..761
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1412
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1419 AA; 161001 MW; A2D2A9C5387DCD04 CRC64;
MGLQLRPAMA PAPDVPADPS DYQEGSVNPW ETLAKKHWLD RAQAPTKVKP DVITNEIWRP
LEQEGFPQRS LAILESCQVL ERFLWPTYST DSSNHHVILI AEFFNLKQRA RLQDWSLFTD
GRPDDFSTLL RRILSLNLDA SLAVHARLSL LNFVLGAFQS LENEHVRKEC APLVSIATWH
NLHDEQARER LLETSPARRK AWRAAARRFD AADPETQSRL RFDRAWLFTM LVDFIARLNV
SKLTHSQDMV YCERFLEFLI DLISQLPTRR YTNPLFQDLN LLPVVRTSKL YEGEDGVLLR
DLANLFEHFQ NFAVDDLGAT EGNDGVRRMH YHALERLQRI SLQHFENKLK VLALSNFGSV
SKRSDLESHF SDLTDDELQQ LCQYLGFRTT YPAAAVITAN RAILMETLLS SFSRPQDFRE
VVNQLSVLPT ADSIYDPALL RNEHYDGSRP LGIPKLNLQY LTLGDFMWRS FQLYQAEAFY
GVRKDMESIV KRMKPKAGRD SSTMFEGFSK MALPISEPAI IEIGPPKVGH VKPSFVRAEV
ILDVSRLSDN IRREWDNLRP HDVVFLMAVR ASDSSRPFTN GNARVEEDEQ RLFTNLRTAE
VVQVLDDNGR ALRDTQTNGY SRPRRRRLLL DLDTTSYAAD KLKSGRVSSD GAPFNVIARR
QGRENNFKPV LETIQSLVSS QTLLPFWLHD VYLGYGDPRS ATYPFIPDRI ESVDYLDTFL
DWHHLTESFP GKTVESTTEQ PAPFSPPYVL KTTSQAGAEL STNPKKRRRD QMEQDSSAVK
VSTYKPRNTG PYPVDVPKKN AVRFTPKQVE AIVSGTQPGL TVIVGPPGTG KTDVATQTIN
LLYHNFPSER ILLVAHSNQA LNQLFQKIIA LDIDPRHLLR LGHGEEELDT EASYSKYGRV
ESFLENRQAY LAEVSRLAAS IGAEGAHGAS CETADYFNRV FIKPAWQRFW DAANAEEAST
ETVLAAFPFF KYFSNAPVPT LFPGDATLDT AKEVASGCQY HIDKIFSELE SIRPFEILRS
NRDQANHLLV SEARIVAMTS THAAMRRSEI AELGFHYDTL VMEEAAQITE IESFIPCAMQ
TPDTKTGELP LKRIVLVGDH LQNSPIIQNL ALRQYANFEQ SLFLRLVRLG VPTVHLDQQG
RCRPSIAQLF SWRYNNLGNL PHLLSQPEFA CANAGFRYDY QFIDVPDYQG AGEREPTPHF
IQNLGEAEYA VALYQYMRLL GYPARSISIL ATYAGQRALI RDVLEHRCKN NSLFGMPRIV
TTVDKYQGEQ NDYVIVSMTR TKSVGYLRDV RRITVALSRA RLGLYILGRR DLFASCFEMK
PAMDLFIQRP DHLSLVTGEM FATTRLLDDD VEEGKVAEME GVEHLGQYVY EMTQAKVKSM
GVQVNNLMED AEEDSGAYVN GEGEELGDDI EEDPLHEAV
//