ID A0A0D2G6S1_9EURO Unreviewed; 1228 AA.
AC A0A0D2G6S1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=PXA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV04_06885 {ECO:0000313|EMBL:KIW67649.1};
OS Phialophora macrospora.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX NCBI_TaxID=1851006 {ECO:0000313|EMBL:KIW67649.1, ECO:0000313|Proteomes:UP000054266};
RN [1] {ECO:0000313|EMBL:KIW67649.1, ECO:0000313|Proteomes:UP000054266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 27337 {ECO:0000313|EMBL:KIW67649.1,
RC ECO:0000313|Proteomes:UP000054266};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capronia semiimmersa CBS27337.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; KN846959; KIW67649.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2G6S1; -.
DR STRING; 5601.A0A0D2G6S1; -.
DR HOGENOM; CLU_002131_1_0_1; -.
DR OrthoDB; 5392990at2759; -.
DR Proteomes; UP000054266; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06876; PX_MDM1p; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..292
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 419..557
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 871..989
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 303..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 835..862
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 707..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1228 AA; 137230 MW; 87E81CEC783AEC9B CRC64;
MMNLARRHVI LAALAAFVAW GLAVRALPVL RFLGYAFTLG SLVTGLACLA ATLTVSRSRS
TYQALSAPPN VSPALLDPQR WPAEVSIVQR CAQYQPSQLY DKSFVVSQAL DTLIGLALRD
FVSSWYQNIT TSPVFVNEVD KNIRTALGEI RDRILNEDMV NVAVSRIVPL ITAHLRDFDR
AERAVRGRSL NRNVTESEEL ELAIAAKYKD GKLHPAAALA YSDTKTVQQE HLRKLLVRIL
PDVLSPTMMA SRATLVLVKE IVACAVLFPI MQMLSDPDTW NQIVEAYGRT TLQDRKTVRR
MRAALDQHAS PTPRSKPDQD LPRLVPNDSE RAFERFVRAI RKTKNLSDAR RFRNSIASQI
QRESMVEGQD PVYLRRLEMA KRVLEQKIEK LTHTGSVPPA AASRPDPRPG PAVKPREWTM
VEIMHTASGL SYVMEYMDRV NRTSLVQFWV VVDGFRNPLE DDFGDEMNPA TQENWTDADR
MDIAQINEKY MLRPELNIPQ ESKDAVKAFL AAGRKATPQQ YRAARTAILA AQSAVLEELE
TRHLPLFRKS DLYYKFLASS EAAAARSRVQ STGNLSEVDE PPPIHRTRPA PQAPSITRNN
SQPAPKAKDL RRAAVSSSDV RSLASSKLFD DGDLPKRSGA SAPLFDDGYD TDPLAHSTAS
LGHESLNGDS VDQRQVIENM EAAMNNIMTD SPMDETMGYD DDTLFGSPVS ATKSSKQIES
PRSSLDFSSA DHANKPRPSL AALGLVNTAS RIGVFTDNDL FPDEEKFIED EYVDNDDDKD
KNAMEDEIHE AAPGDLGLAE AITALNNDIE RLVAQESVVD TLTRKAELTN NVTELRILSK
SKASLQREVR RKELQRQQYI VQESDNSLYG RSSISIKSIV VGKEDDGREF ALYVIEVQRQ
AGDQMPAAVW AIPRRYSEFH ELHQRLRRRY PSTRNLEFPR RRVVMKLQKQ FLQNRRLALE
RYLQQLLQMP DVCRSRELRS FLSQSTITSQ QDTSKESNAQ DIVSRIYNSV TEGMDEFLGN
VPVLDQLSAA GQNLISAATS QLGMSQGEIL PLDPGPVAEA EAELAAFEDK ELEPFVKPIC
DVFLETFELN RGNNWLRGRA VIVVLHQLLG GTIERKVREI VTGFVQENSL IRYIDMIKET
MWPGGGKMRE AKPRTAAEKI KSRSEAAAML ATLVPDLAGN VVGRANAQAA ARRITATMNN
ARLNQHLVFT ILDEIVAVLF DPSKKGLP
//
