ID   A0A0D2G7I4_9EURO        Unreviewed;       738 AA.
AC   A0A0D2G7I4;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN   ORFNames=Z517_09047 {ECO:0000313|EMBL:KIW76603.1};
OS   Fonsecaea pedrosoi CBS 271.37.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX   NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW76603.1, ECO:0000313|Proteomes:UP000053029};
RN   [1] {ECO:0000313|EMBL:KIW76603.1, ECO:0000313|Proteomes:UP000053029}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW76603.1,
RC   ECO:0000313|Proteomes:UP000053029};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC       of dynamic microtubules. Required for mitotic spindle formation.
CC       {ECO:0000256|ARBA:ARBA00024889}.
CC   -!- SUBUNIT: Interacts with microtubules. {ECO:0000256|ARBA:ARBA00011375}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000256|ARBA:ARBA00004186}.
CC   -!- SIMILARITY: Belongs to the CLASP family.
CC       {ECO:0000256|ARBA:ARBA00009549}.
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DR   EMBL; KN846974; KIW76603.1; -; Genomic_DNA.
DR   RefSeq; XP_013280411.1; XM_013424957.1.
DR   AlphaFoldDB; A0A0D2G7I4; -.
DR   STRING; 1442368.A0A0D2G7I4; -.
DR   GeneID; 25308537; -.
DR   VEuPathDB; FungiDB:Z517_09047; -.
DR   HOGENOM; CLU_016100_0_0_1; -.
DR   OrthoDB; 1369289at2759; -.
DR   Proteomes; UP000053029; Unassembled WGS sequence.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:UniProt.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024395; CLASP_N_dom.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR21567; CLASP; 1.
DR   PANTHER; PTHR21567:SF9; CLIP-ASSOCIATING PROTEIN; 1.
DR   Pfam; PF12348; CLASP_N; 1.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053029}.
FT   DOMAIN          52..288
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   REGION          275..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..451
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..404
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   738 AA;  82573 MW;  DB436E99A11D8C23 CRC64;
     MAFFRNHLDF LKATTATTFN QTVKKVDTTI PAVGKAVYFA IAGARAKMLG KTYADVLNLL
     HYELTLPETE ESWKKRQDLL AELSDIFEKR KENSTIPNDF VQKVKAVLPY IVSTAGSERT
     TLSAQACRAL SNIAKHLENQ IQSQLDLLLP GLIAICGSTK MVNQKNANDA IMNICKHAGY
     SPRLFYHVCA AFKDNRIPPR TYAPEWLRIL IETYRSQMDR EKDGPACEKA IAAGLTDGQV
     KVRENSRAVF WTFHSYDPRG ARAIMGTLNT HAQKALKADP HNPDKSSATA AHANAPPRPK
     SALASIKAQN KERMAQTKES SQQRGLTPEP IKSDDFKVFG TMDDTEKKPS LLSAPVRRRI
     VATPMPSAST VQRPDSRGRA ATSASSVSKD NSTNIVPETV PKSSFETVTK SSYETIKSDG
     KENAMVIRPR KKRSPKRSPK RSPERDRLAS EKKTLLMAME ALRRSSLDAL GYRRLRKLIE
     ENPGALITKH SQFNELFELL IHNMASLDMI TEPRDKRATN INHPAYNTHT ILITLVHLFQ
     QYPQWPEPQP GMTLSALLIA RCNHSSSYAS VLSAIDDGAF LLCSHTQTVL PTIDAVLDTL
     EQIECIITDN DPIVTPKSTD TILYNSLQSL ASDFGPERPR LANRLPIVMD FGLKILNALL
     LRVVSCNETL YEIQEDRLAA YAEHLLATYT SIIKRAVMNF CINLHAVIKP EARFYKYFKK
     ESDKNLIHYY VDVAASPY
//