ID A0A0D2GIY8_9EURO Unreviewed; 1030 AA.
AC A0A0D2GIY8;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN ORFNames=Z517_07405 {ECO:0000313|EMBL:KIW80788.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW80788.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW80788.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW80788.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC {ECO:0000256|ARBA:ARBA00002558}.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR EMBL; KN846972; KIW80788.1; -; Genomic_DNA.
DR RefSeq; XP_013284596.1; XM_013429142.1.
DR AlphaFoldDB; A0A0D2GIY8; -.
DR STRING; 1442368.A0A0D2GIY8; -.
DR GeneID; 25306895; -.
DR VEuPathDB; FungiDB:Z517_07405; -.
DR HOGENOM; CLU_003212_0_0_1; -.
DR OrthoDB; 1779375at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.120; -; 2.
DR InterPro; IPR025926; PDZ-like_dom.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR Pfam; PF12812; PDZ_1; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW Protease {ECO:0000313|EMBL:KIW80788.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 326..374
FT /note="PDZ"
FT /evidence="ECO:0000259|Pfam:PF17820"
FT DOMAIN 390..466
FT /note="PDZ-like"
FT /evidence="ECO:0000259|Pfam:PF12812"
FT DOMAIN 868..945
FT /note="PDZ-like"
FT /evidence="ECO:0000259|Pfam:PF12812"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 113357 MW; B29B13F089B2174B CRC64;
MSANGELRLK RRTSPTSALE RPKKQLKPEN GVPTPGNATP QNGSVYDIEA DSTSVPIINP
VPAAGDSPEW QATIERVIKS VVSIHFCQTC SFDTDLSLSS QATGFVVDAE NGYIMTNRHV
VCAGPFWGYC VFDNHEECDV KPVYRDPVHD FGILKFDPKA IKYMNVQALK LQPESARVGV
EIRVVGNDAG EKLSILSGVI SRLDRNAPEY GEGYSDFNTN YIQAAAAATG GSSGSPVVNL
NGHAVALQAG GRIDGAATDY FLPLDRPLRA LQCLQRGEPI NRGTIQTQWM LKPFDDCRRL
GLTPNWESAV RKVHPKENSM LVAEIVLPEG PADNKIQEGD VLIKVNGELL TSFVKLDAIL
DSSVGGKVDL LFQRGGEDHE VTLAVEDLHA ITPDRFVTVA GGSFHNLSYQ QARLYAIACK
GLYVCEAAGS FKLDSALSGW IIDTVDQKPT PDLDTFIEVM KTIPDRSRIV ISYRHIRDLH
TRATTIVHID RHWHPKMRLS VRNDETGLWD FKDLGKALPA IPQVPKSADF IQLDGVNLPA
AAEIIRSFLK ITCYMPVKID GYPQARRTGF GLVIDAEKGL VVVSRATVPY DLCDITVTVA
DSIQIEGKVV FLHPLTNYTV IQYDPSLVHA PVQTAKLSTE MIKQGADTIF VGFNQNHRAV
VAKTTVTDIT AVGIPANAAA PRYRAVNLDA ITIDTGLSSQ CASGVLMSAD GTVQALWLTY
MGERSQGSHR DTEYHLGLAT SMIKPVIDQI RSGIIPKLRI LNMESYVVQM SQCRIMGVSE
EWISKVAKAN PSRHQLFIVR KVDCGPANGP NDGQLLQEGD IILTLNDQLI TRVSDFDIMY
DKEWLDALVV RKGKEIRLRV PTVPTEDLET SRAVIFCGAV LQKPHHAVRQ QISKLHSEIY
VSARSRGSPA YQYGLAPTNF VTHVNGVKTP DLDAFVKEVN KIDDNTYFRL RAMTFDNVPW
VVTMKKNDHY FPMSEYVKDP TKANGWKVIS YGSRGRKTKG EDGAPLTSDS MSAEDDGLSE
GEEGPDRGEY
//
