ID A0A0D2HCL5_9EURO Unreviewed; 889 AA.
AC A0A0D2HCL5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=DUF221 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z517_05301 {ECO:0000313|EMBL:KIW82274.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW82274.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW82274.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW82274.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KN846971; KIW82274.1; -; Genomic_DNA.
DR RefSeq; XP_013286082.1; XM_013430628.1.
DR AlphaFoldDB; A0A0D2HCL5; -.
DR GeneID; 25304791; -.
DR VEuPathDB; FungiDB:Z517_05301; -.
DR HOGENOM; CLU_002458_2_1_1; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF26; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 37..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..185
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 208..404
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 415..688
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 786..881
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 13..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 100195 MW; ED14E963E50C5369 CRC64;
MDVFHAVLSV RQAPDTNPNH DQNVGSSRNS SPSLSGLIST LVPTLVIAVV YFAIFLLLRT
RFPRQYAPRT YLGALRPQER TPAPPNSLFG WISFMRKLPD EYVLQHNSLD GYFLLRYLKM
SIVICLVGCL VTWPVLFPIN ATGGGHQDQL NILSFSNVVD KNRYLAHTFI AWIFIGFIFF
LVTREMIYYI NLRQAYLLSP LYASRMSSRT VLFQAVPNEY ANETKIRRMF GEELKNVWVV
SDAKSLKEMV EERHKICIKL ETAETKLIKL ANDARLQSIK GKNPPPELPT ASYDEDEYAA
ESGAAAARWV RPKDRPTHRL KFLVGKKVDT INWCREEIAR LNPLIEAEQD KYRAGEAVPK
NAVFVEFWNQ TQAQSAFQMV THHQPLHMSP RVVGLSPEEV VWSNLGITWK TLTIRKLVSL
GFIVALIIFW SIPVAVVGSI SQISYLTQVV HFLRFINKCP KIILGVITNL LPVVMLSVLM
SLVPVIMRFM GKVAGMPTLS LIELRCHESY FWFQLIQVFL VTTMTSAASA AVPQIIKQPG
SITTLLAQNL PLASNFYISY FILQGLVFSS GQLLNIVGLV LYNTLSKILD KTPRKMYNRW
SSLSSVGWGS VFPVVELMTV ISIAYAPIAP LMLGFAAIGQ GLFYFAYRYS LLFVDSSVID
TKGLVYAKAL QHTLVGCYLA VICLIGLFGI RAAPAPLVLM VVFLILMVLY HMSMNAAVRP
LLYYLPRSLE AEEAALLHSE SALMTGPDGG PSRPSMHEKH QLDELRVAKE TMPPGGNKHT
SMIKRFFRPD IYASYAILRK LVPQEFAEIR YSPEIERDAY QDPACNAVAP LLWVPRDPMG
VSRQECLHTN KVTPMTDEGA SFDEKTGRII WNEEETGGQP PIFEEKIYY
//
