ID A0A0D2HIH2_9EURO Unreviewed; 554 AA.
AC A0A0D2HIH2;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=MATE efflux family protein subfamily {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z520_01854 {ECO:0000313|EMBL:KIY01716.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIY01716.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIY01716.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIY01716.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
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DR EMBL; KN848064; KIY01716.1; -; Genomic_DNA.
DR RefSeq; XP_016635838.1; XM_016772368.1.
DR AlphaFoldDB; A0A0D2HIH2; -.
DR STRING; 1442371.A0A0D2HIH2; -.
DR GeneID; 27707600; -.
DR VEuPathDB; FungiDB:Z520_01854; -.
DR OrthoDB; 661905at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206:SF113; MATE EFFLUX FAMILY PROTEIN (EUROFUNG); 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053411};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 133..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 60099 MW; 6B96EC6736151AFE CRC64;
MRRYSSTGKS RPDTATQKYP SSRDGSAEED HDRRRSVALM SEDIQREEPD EQTGLLPKKR
HDEEQASSQE EGELLDILPE DETPRRKLIL HEFWVLFRGS VPVILAYSLQ NSLQTISILI
VGRASPQDLS TAAFSYMFAM CTGWLIGMGG STALDTLASS TFTGSKNKHD LGILLQRAFI
VLTLFYVPVA ILWLCSGPVF RALGQSDQLS RDSSKFLSCL IPGGLGYIYF ETMKKYLQAQ
EIMRPGTYVL LITSPISALL NYLFVYVAGW GIFAAPFATG IGYWLSFLGL VLYAKFVAGG
ECWGGWTKRC LQNMGVFAKL AALGVIHVGT EWWAFEIVAL AAGRLGEIPL ASQSVIMTAD
QVMNTIPFGI GVAASARVGN MLGSRNAKGA ARSANVAAWL SMFMGAVVLA ILMGTKNVFA
KIFNDDERVV KLTAHVLPYV ALFQIADGLN GSCGGSLRGM GRQHIGAAVN IVSYYCGALP
LGIWLAFHGW GLPGLWVGQC IALYLVGIAE WAIVAFSNWE HEVDKAFARM DKDELVEGGH
AGGSVPAPAG NGPQ
//
