ID A0A0D2HKS3_9EURO Unreviewed; 327 AA.
AC A0A0D2HKS3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Autophagy-related protein 27 {ECO:0000256|ARBA:ARBA00013776};
GN ORFNames=Z520_02600 {ECO:0000313|EMBL:KIY02461.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIY02461.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIY02461.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIY02461.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004358}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Preautophagosomal structure membrane
CC {ECO:0000256|ARBA:ARBA00004472}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004472}.
CC -!- SIMILARITY: Belongs to the ATG27 family.
CC {ECO:0000256|ARBA:ARBA00005363}.
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DR EMBL; KN848064; KIY02461.1; -; Genomic_DNA.
DR RefSeq; XP_016636583.1; XM_016773113.1.
DR AlphaFoldDB; A0A0D2HKS3; -.
DR STRING; 1442371.A0A0D2HKS3; -.
DR GeneID; 27708346; -.
DR VEuPathDB; FungiDB:Z520_02600; -.
DR OrthoDB; 1332975at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.70.130.10; Mannose-6-phosphate receptor binding domain; 1.
DR InterPro; IPR018939; Autophagy-rel_prot_27.
DR InterPro; IPR009011; Man6P_isomerase_rcpt-bd_dom_sf.
DR InterPro; IPR044865; MRH_dom.
DR PANTHER; PTHR15071:SF38; AUTOPHAGY-RELATED PROTEIN 27; 1.
DR PANTHER; PTHR15071; MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF09451; ATG27; 1.
DR PROSITE; PS51914; MRH; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053411};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..327
FT /note="Autophagy-related protein 27"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002243766"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..241
FT /note="MRH"
FT /evidence="ECO:0000259|PROSITE:PS51914"
FT REGION 164..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 327 AA; 36684 MW; 844975A2B2D25035 CRC64;
MKTPVYALLP LLLSLSHLAA SVSIDCQHIR VDGKKFDLSK LAGRHSVSVH DTSRPPAEYN
TTWTIDLCAP LKKLEGIRDQ DQCPHGTRVC GVVRSWNPAD DPEKKHVQVE NVIPIAGNFE
SSTGAGLDPK VTRLKAQDAN SDGLQIELNG GNYNHMKQKA VVQLTCDKDR TGNEEKRKRS
RKQKKRDDDG EDSDKDKDKN KDEVEQPSTS SLEFVSYGQV EGKDKVEVLR LNWRTKYACE
DYADSDEATR KSGWGFFTWF ILIAFLGIAA YLIFGSWLNY NRYGARGWDL LPHGDTIRDI
PYLFKDWSRK VIDTVSGGGS RGGYSAV
//
