ID A0A0D2HNK3_9EURO Unreviewed; 757 AA.
AC A0A0D2HNK3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=AMP-dependent synthetase/ligase domain-containing protein {ECO:0000259|Pfam:PF00501};
GN ORFNames=Z520_00077 {ECO:0000313|EMBL:KIY03386.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIY03386.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIY03386.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIY03386.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN848062; KIY03386.1; -; Genomic_DNA.
DR RefSeq; XP_016637508.1; XM_016770598.1.
DR AlphaFoldDB; A0A0D2HNK3; -.
DR STRING; 1442371.A0A0D2HNK3; -.
DR GeneID; 27705823; -.
DR VEuPathDB; FungiDB:Z520_00077; -.
DR OrthoDB; 45466at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921:SF4; ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770); 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053411};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 201..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 153..542
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT REGION 29..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 83958 MW; 3AD0E739DEE8168F CRC64;
MPSSPAAYYN AVGLPLEYCS KQYRDEIKWG SSPPSNPAGP SSSASSNSNG TSSPPTPLWT
PPDPEAPPMS QYRHHVNAKF SQSLRNSHDL HSWTVQNPHQ FWIDLYTYCG IVPPLPKHTK
LAYDPSLRLR DIPTFFPGLK LNYAENVLVP NTRNNPDAVA LVGLRENRLD DPEEVTWAEL
TELVRLARSA MARRGIKQGD VIAGLMANSV WIVVLFLASA SMGAIFTSVS PDLGVSGCVS
RFAQVEPKWL FADVDVAVRG TRPSMLGKVM QILKALPAAK AKPRLVFVPT THRPHRQRHM
DYITPVAGAV SLHEFLTAAR AGDKLSYKRV PTDHPLVIVY SSGTTGEPKC IVSPHVSILN
YKKISLLHNG LGPRSTVFQY SSTSWILWNV MNGHLSVGSK VICYDGGALH PDPSTMLRIV
AQYRATYWGT SPRYLLELEQ SSINPQSFDL SSLQLITTTG ATLTGEQFHW FYRAFPPRIH
LSSVAGGTDI ASSWIATNPA GPVYANEMQM WALGHDCDIL DSNTGKSCAE EGRPGELVCR
KPFPSMPCRF WGDTKDHKKY REAYFEKFPV ATKDSAATAG GGEDEYLDVW AQHDFIVMNP
VTRGLQILGR SDGVLNPSGI RFGSSEIYNI VEGPQFNTLI SDTLCVSRRR ATDQDETVFL
FVVMSPGHEH HFTPQLVAQL KAAVREGLSP RHVPKFVERV RDIPYTVNGK KVEVAVKRVI
SGQKVQVSST VRNPECLREY ERFVDLEREP PSRKAKL
//
