ID   A0A0D2HPT1_9EURO        Unreviewed;       829 AA.
AC   A0A0D2HPT1;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN   ORFNames=Z520_00547 {ECO:0000313|EMBL:KIY03856.1};
OS   Fonsecaea multimorphosa CBS 102226.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX   NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIY03856.1, ECO:0000313|Proteomes:UP000053411};
RN   [1] {ECO:0000313|EMBL:KIY03856.1, ECO:0000313|Proteomes:UP000053411}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 102226 {ECO:0000313|EMBL:KIY03856.1,
RC   ECO:0000313|Proteomes:UP000053411};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   EMBL; KN848062; KIY03856.1; -; Genomic_DNA.
DR   RefSeq; XP_016637978.1; XM_016771068.1.
DR   AlphaFoldDB; A0A0D2HPT1; -.
DR   STRING; 1442371.A0A0D2HPT1; -.
DR   GeneID; 27706293; -.
DR   VEuPathDB; FungiDB:Z520_00547; -.
DR   OrthoDB; 5474206at2759; -.
DR   Proteomes; UP000053411; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053411};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          445..702
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   829 AA;  95447 MW;  B0E7AA8FED29A5E5 CRC64;
     MEVDHKMQSA STRHAADAFA NMYEFNSTRL KKENLNDPAS VPENGRPKPA FANQRVPFNP
     QMGPKKLVVK NLRAATRLDT RAYFEKTWKE NDKALDAIFR NEKDPYSLEE LYKGAEHTCR
     HGHSADLYEL LSAKCETHLN DNVRDRIRRE EAQSSDVDVV RAFVNAWQTW QKQLQTVRQI
     FFYMDQTYCL RTPDKMSVLQ MGLTKFRSSV FYDPFIRNKA LQGVIVLIDS DRRGNLNESD
     SRLLRQSVDT FHELSIYTSD LEPILCVTTG EYFQAWRDSE SNKDSLGDYV NNCTDLLTRE
     MARCDSLSLD RNTRIRVSRL FDSILVEEEL ETLTNEDGIL DLLEDDKSAE LERLYTLLQR
     KGHGELIAPS FSKYVETEGS LIVFDEKRES EMVIRLLDFK RRLDHYQKYS FHGNEALGNA
     LHKAFETFIN KTKKSQSNWD TDNAKPGEMI AKHVDLLLKG GVKAVPRLQT HKHDPSKAEE
     EHDFDDAAAE DAEINQHLSD ALDLFRFVHG KAVFEAFYKK DLARRLLMGR SASFDAERNM
     LTRLKNECGA AFTHNLESMF KDMDLAREEM MSYNQLLDDR GGRAPGLPDL HVNVLSAAAW
     PTYPDVAVNI PPHIAKVMSD FETHYKAKHS GRKLTWKHSL AHCQLRAKFP KGNKELMVSG
     FQAVVLLLFN DIPADKHLTY DEIKAASGLV DAELKRTLQS LACAKYQVLR KHPKGRDVHE
     TDTFTFSQSF SDQKLRIKIN QIQLKETKEE NKETHIRVAA DRHYETQAAI VRIMKSRKKI
     GHNELIVEVI KATMSRGVLD QADIKRNIEK LIEKDYMERE EGNTYSYVA
//