ID A0A0D2I3Z6_9EURO Unreviewed; 3183 AA.
AC A0A0D2I3Z6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Vacuolar protein sorting-associated protein {ECO:0000256|PIRNR:PIRNR037235};
GN ORFNames=Z520_12292 {ECO:0000313|EMBL:KIX92021.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIX92021.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIX92021.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIX92021.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. May play a role in mitochondrial lipid
CC homeostasis. {ECO:0000256|PIRNR:PIRNR037235}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545, ECO:0000256|PIRNR:PIRNR037235}.
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DR EMBL; KN848113; KIX92021.1; -; Genomic_DNA.
DR RefSeq; XP_016626144.1; XM_016782778.1.
DR STRING; 1442371.A0A0D2I3Z6; -.
DR GeneID; 27718038; -.
DR VEuPathDB; FungiDB:Z520_12292; -.
DR OrthoDB; 199953at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-UniRule.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IEA:UniProtKB-UniRule.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR017148; VPS13_fungi.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR PIRSF; PIRSF037235; VPS13_fungi; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037235};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|PIRNR:PIRNR037235};
KW Reference proteome {ECO:0000313|Proteomes:UP000053411};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037235}.
FT DOMAIN 2..115
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..376
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 601..837
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1953..2528
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2780..2955
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3052..3157
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 561..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1052..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1556..1589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1715..1782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..901
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1383..1406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1574..1589
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1740
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1741..1782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3183 AA; 357624 MW; 4A82E86E77BEA0C8 CRC64;
MLESLVANLL NRFLGMYVKN FDPKQLNVGI WSGDVKLRNL ALRREALDQL HLPINVVEGH
LGELTLSIPW SNLRGKPVKV NIEDVFLLAA PKEEDDYDPV EEDKRAVAVK LEKLESAELL
KERNTEAMSP EEQQKSQSFT QSFVTAIVDN LQVSIKNVHI RYEDSIATPD HPFAVGLTLK
EMSAVSTDAD WQPTFIQSTS ETTHKLAVLN SLALYWNSDA DLFGTGKGGD VGAEAQEIDK
DELLRRFREG IEDTSHSQYL LKPVSGRAGI EMDKTGKTDK AKTKARLLFQ ELGFIIDDEQ
YRDALMLVDL MHYFVRHHEY KKDAPKESPK ENPRAWLKFA GNAVLTKIHD RNRKWTWEYF
KERRDTRRRY IELFKKKKKE QKFTEQETKD LTQLEHDLSY EDLRFWRSLA RTQLRKENVG
VKKPAQKQTW SSWIWGAKGQ AEQSSENDEE AGMTEQQRKE LYNAIDWDEK KAIAESVDMP
RESVKLEVES SLRTGSFTLK RDPHGQETEV LKLVFDNFKA KALQRPDSFL AELALGGFRV
YDGTTEGTLF PQIVKVKGVE NQPKDEVKQD GTEDLDDEAE SESAVAEKGE QEEDSLFHLV
FENNPLDESA DTKVDLKLKS LEFIHNPKFV VEIVKFFKPP ERQMESIGAL LETAGATVEE
IRQQTRAGLE FALEEHKTIN ANLDIHAPIF IIPESITEKS TLCMILDAGH VSLNSELVDK
ETMRDIHGKQ KQKYTEEDYR QLEGLMYDKF HLKLESTQVL IGPGIEETRA QLEAEDDSQS
MHIIDRINMA FLLENSIIPK APDITKVRIS GTLPVLHASI SDKKYKNIMR LIDVAIPKFD
TAETEANGTA VESRPQKATE DQASKRKSVQ LLEAKDIPII DHDSDSEDAP TKKDSRNKPE
TPANIHQRNF EINFTVEKLQ ASLYKADPDG KKPDQLLVEL VAERFYFDFY LRPYDMVAQV
LLRSLSVDDH IEEEPLPEFK QIISSKGFNA EEGKDLLNVK FVKVNPESPE FQSTYESIAT
NLDVAMSTIN VIVTRRTLLT LLDFVLTTFT SPGDQQATQE DTDEPEERAD DPRPAEPQAD
KIRIKAQLTS IALILNNDGV RLATLSLNSG DVGVFLDAGT MQVKARLGSL SLVDDINEGA
PEDSPLRRLI AIEGDDLADF KYQTFDSSRK DYPGYDSGIY LRSGSIKVNF LEEPFRKIME
FGVKFGKMQA IFNAARQAAA NQATQVQESA QKMHFDVIIK TPIVVFPRAM VEDRPRDLLT
AYLGEIYANN KFVGVQGQKG GPLVNKLAAG IRHIRLTSEF HYSDGSSQEL EMIDKVDLDF
KIRYLEHQAG IERPDLEIDG SMSPINLRVS HTQFKFLMEL SKTIPAAFAT DDESEEDVAE
ELPSSTTESA KAAEPETTTS ESLAKPSYQG PELGTGEETW TKLNLVFKAP MIALELMLAD
EDRPIENLEA ASLSKFSINE TNIKLRMISD GAMEAELVIH SFTVRDSRTK ETNKFRKIMS
LINNDVQQQF MASLSITGGE ERHMIVMLTI DSPRVIVALD YIFALQAFAN TALQSDEPPP
IAEVDDLTER SDPSLENDQG QMESGAQEVE SAGQSSMTIS FRLNVVDAQV ILIANPTISN
TEAIVLGTKE VLVSKQNAMT LQVSKVGMFL CRMDRFETSR LRILDDFSIQ MSMDNRSQGK
ESSLTSIHIG IEPLVLRLSL RDILLAMQIV SKASSTTAQP KMQEDTEPKK LKDVKASSKA
PSTKRKSIAA TSTAAQRSKR SKSVSKSTKS GSQQQSSKSV VMSREEMVAQ IEGIRVILIG
DMHELPLLDW SVKKFDVDVR DWSSSLTADT KIDTFINVYN FSKSAWEPLI EPWNLGFHMS
KQLHPEVLSM ELYSHKNMEL TITSATIALA SKSFDFLSTD EDILSKPRVA DAPYRIRNYT
GFDLSVWADE KSESAAAAKL TDGEEYAWRF EDATSMRESL SPEGNAGLVG VKLEGSGFDS
VVRIPVIREG ETLYNLKPRK DGVQHRMLVE VRLGSDNVKY ITFRSPLLVE NKTQIPIEVG
VYSPDDGHLL KIEKIAPGEG KPAPVGAAFV HSLVLRPDQG FGYGWSNERL FWKDLLRRQT
RALTCESEGR DESPPFFFQM HASYDDKDPI TKIYPFMRIQ VSAPVEIQNL LPYDFKYRIY
DKNTKKDWTN FLRKGGVSPV HVVELSHLLL LSVEVEDAPF KQSDFAIINS DTQEGFRREK
VLQLKDERGA QLRLKLHYTN IKDSGGAFRV SVYSPYVLLN KTGLDMSVQS KAFLGSSTKA
SSPQGARTSA GEGTALPMLY SYGSDDRKNR SLIKIGDSTW SKPQSFDAIG SSYEVVLPSA
SGKSEMHVGV SVAEGEGKYS LTKVVTMAPR FVLKNKIGED IELREPGSSE VWKMKNNDLL
PMYFMRQSPE KQLCMCFPGV NNQWSSPFNM ANVGMTHVKL AKHGQRQKLV RVEIILEDAT
LFLHFSIETK HWPFSMRNES DTEFLFFQAN PNLGEDEEED KGSGWKPIRY RLPPRSIMPY
AWDYPASKNK ELVLTAGGRE RYVKLAEIGN LIPIKLPPDD RGGPMKVIDI NIVADGPTQT
LVLSNYKPSR SMYRQKTGMT TASQTSLNQG FEVKQIESEV NFKAELRLAG IGISLVNSKL
KELMYVTFRE MDLKYGDSKL YQTLNFTVKW IQIDNQLYGG IFPILLYPSV VPKTGKEMEA
HPIFHTMVTR VKDDSYGVLY IKYATLLLQQ ITVELDEDFI FAMLDFAKVP GASWSEEKEG
KLCDESLDVP EPTREEQGQD VYFELLHLQP IQLDLSFVRT ERVNAEDNFV NSPLMFIVNV
MTMSIGNVND APIRFNALML ENARISVPAL IANIQNHYTQ EALRQVHIIL GSADFLGNPV
GLFNNISSGV ADIFYEPYQG LVMTDRPQEL GIGIAKGASS FVKKSVFGFS DSMAKFSGSI
SKGLAAATMD KEFQDQRRMS KSRNRPKHAL YGVTAGGNAF AASMASGIGG LARHPLEGAE
KEGALGFVKG VGKGFLGLAT KPAIGAFDLA SNVAEGVRNT TTVFDSEGLD RVRLTRFIGM
DGIVRPYSQR EALGQFWLKT CDDGRYFNEE YIAHLELEGG DMMVVITYER ILMIRTKKLR
MEWDIKLTDV QTISKERTGM SIGLKGGANG PFIPVADEGS RNWLYKQIAI AVNAFNDKYN
AKG
//
