ID A0A0D2I5A9_9EURO Unreviewed; 475 AA.
AC A0A0D2I5A9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Zinc transporter {ECO:0000256|RuleBase:RU369017};
GN ORFNames=Z520_11886 {ECO:0000313|EMBL:KIX92411.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIX92411.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIX92411.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIX92411.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a zinc transporter.
CC {ECO:0000256|RuleBase:RU369017}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU369017}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU369017}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily.
CC {ECO:0000256|RuleBase:RU369017}.
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DR EMBL; KN848105; KIX92411.1; -; Genomic_DNA.
DR RefSeq; XP_016626534.1; XM_016782373.1.
DR AlphaFoldDB; A0A0D2I5A9; -.
DR STRING; 1442371.A0A0D2I5A9; -.
DR GeneID; 27717632; -.
DR VEuPathDB; FungiDB:Z520_11886; -.
DR OrthoDB; 2730679at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:InterPro.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR045316; Msc2-like.
DR PANTHER; PTHR45755; -; 1.
DR PANTHER; PTHR45755:SF5; ZINC TRANSPORTER; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU369017};
KW Ion transport {ECO:0000256|RuleBase:RU369017};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369017};
KW Reference proteome {ECO:0000313|Proteomes:UP000053411};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369017};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369017}; Transport {ECO:0000256|RuleBase:RU369017}.
FT TRANSMEM 151..168
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 180..198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 261..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 305..326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT TRANSMEM 338..355
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369017"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..23
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 51858 MW; 89D39764A63310DD CRC64;
MANTMPIPLP PRTPTPPPDE TSSPQKPAVF DSDPPYDPKS LSPHQYDPEY MPSSGAAYFS
PTTPEKQSAG GNVNGNGAGP FNFQPSTLAK SPVIKSNIGQ RRGHKYKHSS VSHQIFLEPP
PRAPLALPNS LPIPTFAECR ASMTKDQKVR FYWSICHMAI AGYTAWNSHG SSAMEALSHL
IFYDSLGALL CVLVEVLSNF EVWGRSSVRH PFGLQRMEVI AGFALSVLLI FFGFDLISHN
AKHALEGIGH EPHHPHTHEQ VTAGTVDVTA ILALVATLIS AVGLQNHARI GKAMRFAAME
NLPSLLSNPC HFLTLSCSAT VLLLPLLDLH TYEWMDKALS LSIAFSMLFL GFHLGRNVGS
MLLMSLPSKS ASALSEVVET IESDPLVRAV EQAKFWQAHY GTGMANLRLR VVGSEENLVK
LRERIMSIVR NKLSGGYGLG SSGQKWEISV QFKVEVETAM SASHSHFMSP QSWVA
//
