ID A0A0D2ILB2_9EURO Unreviewed; 1349 AA.
AC A0A0D2ILB2;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=RhoGAP-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z520_06594 {ECO:0000313|EMBL:KIX97816.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIX97816.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIX97816.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIX97816.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN848073; KIX97816.1; -; Genomic_DNA.
DR RefSeq; XP_016631939.1; XM_016777094.1.
DR STRING; 1442371.A0A0D2ILB2; -.
DR GeneID; 27712340; -.
DR VEuPathDB; FungiDB:Z520_06594; -.
DR OrthoDB; 25690at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13277; PH_Bem3; 1.
DR CDD; cd06093; PX_domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF137; GTPASE ACTIVATOR (BEM3), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06400)-RELATED; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000053411};
KW Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT DOMAIN 767..879
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1022..1227
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 256..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1299..1329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..545
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1349 AA; 148453 MW; 6D21EF6D7F5AAF26 CRC64;
MSQSTAHTLP PQSPQDRLAQ TTAVVSTSSL ASPHSYILAS RKPQSPAVLQ GSLIPRDYLS
SLSSSRAIPT QQRKIEEEDD DLYGKAPAPN DSGKRHVQNT TEGEAALTRE KGYDGTAPPN
EQEGSVSSRS HSQKDQGVTP LFESPKSYAS SSTSVHPPNN MPRTSSIDSA ISSISNASHA
QKHLGEVKEP SREEVQNLIA TAGSAENLIQ HLLKDKGHAA AQNAQLWKLV DKQRALLLGL
NKDLERLTKE RDRYRKKVKE LQAQPSTSQV DRLRLEEGNS PQSDGEVTLP LGDYGASLRT
EEQTPIKGLS SMQVHSSPID AAMMPSPLHL QQQPPKMQSL ATQLAQPSFA LTEATPLTEK
PPKSFQASRK APPKPLDLRP AKEEFPADQV IVPTDVIVSG DEDEEERDPI SRGRRKTREE
DDRDRELLAL KEQEARSRSK KEKKAKPEAE EPTVLDQMPL PPAVAEVTQP LPLRQDHLSP
ASITSGSVGS SAQLSLPLRS PGLPMSPRPM MGSALPMSPR VPAGNFPLSP RAPKMPLPMP
TTPGQQAPNP QALAQAQAAA SDSQKKTVPS SLSKMNTATG AELDRGQIHE SPLSPGEVPA
VSRGLVDPSW PDLLLPPNAL PSIQVKVASS RLRPARNSML GLRMAEENAV FSLSIFERAT
SSELWRVEKI PTSLPTLEQQ LRSRCPDLPK LPDRKLFSGH SPAVVDARRN AINDYFDDLL
DTPMDEQAAA VICRFLSTDV MEPQLTIPLH NSENAQSRQV TQSNSGIPTK SGYLTKKGKN
FGGWKSRYFV LDSPELRYFE APGGAHLGTI KLLNARIGRQ TQSDPASNAE VDSENQYRHA
FLILEPKRKD MNSHVRHVLC AESDAERDEW VETLLHYIDE RPAEPRSQYG AGIQSSHAKD
GKVSQRMGQE DAESKSNGSP QTHSNTPSPS IASSQTPELV QEPVTVSKPY NISGPMNGAV
ISDAGSWGNK SASSSGSKER EQKKRNLFHF RKPSYEQLAP VQPAHPKNNV HRGGHVRPVF
GMQLQEAVEY YSPVDVEVYL PAVVYRCIEF LRAKNAANEE GLFRLSGSNI VIRLLKDRFN
TEGDVDLLAE DEDYDVHAVA SLFKTYLREL PSTILTRELH LEFLKGLELP DKSQKIVAFN
LLVHQLPSAN FSLLRTLSQY LLEVVQNSER NKMTIKNVGI VFSPTLNIPA PLFALLLTDF
ESIFDKPADR ESVRSTELEL ERGEGALTPE DIRSPRRQMF TDLPTPMYNQ DSFAQNARAT
GGMQASARPE YQLDAPNELG FAPIQPSYES RQYVSFPHEA PMSAPRYPPP QPPNQHGGSN
QYGGSNNMMA PENAASVRAR RRESSMLFM
//
