ID A0A0D2IYG3_9EURO Unreviewed; 887 AA.
AC A0A0D2IYG3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DUF221 domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z518_03072 {ECO:0000313|EMBL:KIX08416.1};
OS Rhinocladiella mackenziei CBS 650.93.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Rhinocladiella.
OX NCBI_TaxID=1442369 {ECO:0000313|EMBL:KIX08416.1, ECO:0000313|Proteomes:UP000053617};
RN [1] {ECO:0000313|EMBL:KIX08416.1, ECO:0000313|Proteomes:UP000053617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 650.93 {ECO:0000313|EMBL:KIX08416.1,
RC ECO:0000313|Proteomes:UP000053617};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Rhinocladiella mackenzie CBS 650.93.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN847476; KIX08416.1; -; Genomic_DNA.
DR RefSeq; XP_013275552.1; XM_013420098.1.
DR AlphaFoldDB; A0A0D2IYG3; -.
DR GeneID; 25291143; -.
DR VEuPathDB; FungiDB:Z518_03072; -.
DR HOGENOM; CLU_002458_2_1_1; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000053617; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF26; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053617};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 631..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..186
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 209..404
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 415..688
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 785..872
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 14..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 887 AA; 99904 MW; BC7E9BA136730094 CRC64;
MDVTLNAVLN IRQAPSTDSD DDENIGSSRE GSPSISGLIS TLVPTLLIAA VYFAIFLIVR
TKFPRQYAPR TYLGALRPQE RTPAPPNTLF GWIPFMRKLP DEYVLQHNSL DGYFLLRYLK
MAILICFVGC CITWPVLFPV NATGGGGQEQ LNILSFANIQ DKNRYFAHVF IAWIFIGFVF
FLITREMIYY INLRQAYLLS PLYASRISSR TVLFQAVPEE YANEAKIRHM FGEELKNIWI
ASDAKELEDM VDERYKNCIK LEAAETKLIK LANDARLKSL KGKKPDTEQP AAHYDEEYGS
ESGSAAARWV GPKDRPTHRL KFLIGNKVDT INYCREEIAR LNPLIEAEQN KYRSGDSKPK
NAVFVEFWKQ TQAQSAFQMV AHHQPLHMSP RVIGLSPEEI VWSNMGITWR TLTVRNIFSL
AFVTAMIVFW SIPVAVVGSI SQISYLTEVV PFLSFINNCP DVILGVITNL LPVVMLSILM
SLVPVIMRFM GKVAGKPTLS LIELRCHESY FWFQLIQVFL VTTMTSAASA AVPQIIENPG
SVTTLLAQNL PLASNFYISY FILQGLVFSS GELLRIAGLV LFNVMSSILD KTPRKMYNRW
SSLSSVGWGN VFPVLEMMTV ISITYAPIAP LMLGFATIGL GLFYFAYRYN LLFVDSSVID
TKGLVYAKAL QHTLIGCYLA AICLIGLFGI RAAPAPLVLM VVFLVFMALY HISLSSAVAP
LLHYLPRSLE AEETALLQTE SAVTTAADPR RDAMREKNAL EELRKVKETM LPTEGNKKVS
MFKRFLRPDI YASYTVMRKL VPQDFAEIRY SPEVARDAYQ DPAVNAVAPL LWVPRDEMGV
SRQECLHTNK VTPMTDEGAT FDEKGKIIWL QEELGGRAPI FEEKIYY
//
