ID A0A0D2J6E7_9EURO Unreviewed; 301 AA.
AC A0A0D2J6E7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Tethering factor for nuclear proteasome STS1 {ECO:0000256|ARBA:ARBA00016204, ECO:0000256|RuleBase:RU368013};
GN ORFNames=Z518_05485 {ECO:0000313|EMBL:KIX04615.1};
OS Rhinocladiella mackenziei CBS 650.93.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Rhinocladiella.
OX NCBI_TaxID=1442369 {ECO:0000313|EMBL:KIX04615.1, ECO:0000313|Proteomes:UP000053617};
RN [1] {ECO:0000313|EMBL:KIX04615.1, ECO:0000313|Proteomes:UP000053617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 650.93 {ECO:0000313|EMBL:KIX04615.1,
RC ECO:0000313|Proteomes:UP000053617};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Rhinocladiella mackenzie CBS 650.93.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC turnover of proteasome substrates. Targets proteasomes to the nucleus
CC and facilitates the degradation of nuclear proteins.
CC {ECO:0000256|ARBA:ARBA00025651, ECO:0000256|RuleBase:RU368013}.
CC -!- SUBUNIT: Binds the proteasome. {ECO:0000256|ARBA:ARBA00011464,
CC ECO:0000256|RuleBase:RU368013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368013}.
CC Nucleus {ECO:0000256|RuleBase:RU368013}.
CC -!- SIMILARITY: Belongs to the cut8/STS1 family.
CC {ECO:0000256|ARBA:ARBA00006199, ECO:0000256|RuleBase:RU368013}.
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DR EMBL; KN847478; KIX04615.1; -; Genomic_DNA.
DR RefSeq; XP_013271751.1; XM_013416297.1.
DR AlphaFoldDB; A0A0D2J6E7; -.
DR STRING; 1442369.A0A0D2J6E7; -.
DR GeneID; 25293556; -.
DR VEuPathDB; FungiDB:Z518_05485; -.
DR HOGENOM; CLU_033658_0_0_1; -.
DR OrthoDB; 2720936at2759; -.
DR Proteomes; UP000053617; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:UniProtKB-UniRule.
DR GO; GO:0031144; P:proteasome localization; IEA:UniProtKB-UniRule.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.58.1590; Tethering factor for nuclear proteasome Cut8/Sts1; 1.
DR InterPro; IPR013868; Cut8/Sts1_fam.
DR InterPro; IPR038422; Cut8/Sts1_sf.
DR PANTHER; PTHR28032; FI02826P; 1.
DR PANTHER; PTHR28032:SF1; FI02826P; 1.
DR Pfam; PF08559; Cut8; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU368013};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368013};
KW Protein transport {ECO:0000256|RuleBase:RU368013};
KW Reference proteome {ECO:0000313|Proteomes:UP000053617};
KW Transport {ECO:0000256|RuleBase:RU368013}.
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 301 AA; 34211 MW; 866CC3503E4AFFD0 CRC64;
MNSLATPPIP PHFHEHTRLS PNRSMSAAGP SRKRKASPSP DRDDEMLTSP SLSSARLPQI
TTPTSRKRVR PNLAGRPLSV DRLLETLDKE SLTAVVKSLC GRNPGLRDEI VQVSPRPSIQ
STLQVLRQYY DRLMGSFPLD PNPRSDYSYD RVRPQWHEML DALADFTPHF LPPNEQQSSI
SLEYLNGVTQ IIHDLPEWDN AQHNLAKQNA YEEISKAWAS VIKEAGKRGG GIQLQYNGWE
EKLRVHNEKS GGRLREAYEA WVDALGWLKP TTQPFQQQSI RQQLFSNTYG MEQPVIRTGN
W
//
