ID A0A0D2J8H0_9EURO Unreviewed; 749 AA.
AC A0A0D2J8H0;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=Z518_06267 {ECO:0000313|EMBL:KIX05395.1};
OS Rhinocladiella mackenziei CBS 650.93.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Rhinocladiella.
OX NCBI_TaxID=1442369 {ECO:0000313|EMBL:KIX05395.1, ECO:0000313|Proteomes:UP000053617};
RN [1] {ECO:0000313|EMBL:KIX05395.1, ECO:0000313|Proteomes:UP000053617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 650.93 {ECO:0000313|EMBL:KIX05395.1,
RC ECO:0000313|Proteomes:UP000053617};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Rhinocladiella mackenzie CBS 650.93.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00000600};
CC -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC {ECO:0000256|ARBA:ARBA00007913}.
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DR EMBL; KN847478; KIX05395.1; -; Genomic_DNA.
DR RefSeq; XP_013272531.1; XM_013417077.1.
DR AlphaFoldDB; A0A0D2J8H0; -.
DR STRING; 1442369.A0A0D2J8H0; -.
DR GeneID; 25294338; -.
DR VEuPathDB; FungiDB:Z518_06267; -.
DR HOGENOM; CLU_001666_8_2_1; -.
DR OrthoDB; 170190at2759; -.
DR Proteomes; UP000053617; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR CDD; cd18044; DEXXQc_SMUBP2; 1.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 2.40.30.270; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR048761; SMUBP-2_HCS1_1B.
DR PANTHER; PTHR43788:SF19; DNA-BINDING PROTEIN SMUBP-2; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF21138; SMUBP-2_HCS1_1B; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053617}.
FT DOMAIN 209..446
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|SMART:SM00487"
FT DOMAIN 227..608
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 433..467
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 749 AA; 82965 MW; AF6EF2574B5789C8 CRC64;
MAPPNALPPS AFFTTLLTLL SLEQDSEIAE TTLLLSSAPL STLSRAGLAI LNLSIQSLKT
GLGGRSVVEL GLDSAIVSKD TKGELPEHGI RTGDIVRLAE MPKGTAKKKE VSELKGKGVE
GVVIRVGERA VWVALGKEGN GSEDVEGVPD GKLWLVKLAN DVTYKRMNQT LTKLLETSES
SYTMLQRVLL GLSFPGTPDM DKVKDIVFFD PTLNASQRDA VRFALSSPEI ALIHGPPGTG
KTYTLIELIL QLLKDGQRVL VCGPSNISVD NIVERLALTS PGTPIVRLGH PARLLPGVLN
HSLEVLTRTS EAASIVSDVR KEMDEKQASI RKSRNGRERR AIYADLKELR KEYREREGKC
IDGLVKGSQV VLSTLHGAGG RQVRNEKFDV VVIDEASQAL EPQCWIPLVL CGGNVQKLVL
AGDHLQLPPT VKSVDNKDNK DDKKAKMKEL EEDLAKLSVK DEEMRIARNW SLETTMFDRL
LGMHGPKIKR LLNTQYRMHE KIMRFPSDEL YEGKLVAADA VKARLLKHLP YQVKETEDTV
EPLVFYDTQG EDFPEKTEDD SGGSVKKSIL LGDSKSNEME AAVVAMHVRN LMEAGLRDED
IAVVTPYNAQ LAILSSMLKE KYPNIELGSV DGFQGREKEA VIVSLVRSNA EKEVGFLGEK
RRLNGKFNLP MRLRLIFPFI LTARKRQHCP VSASQRRICS GHHYSRPIMS DHLDSCDDPT
KKAFMYSWRF GNSVERQSIS QEVDEIPRG
//
