ID A0A0D2JJF2_9EURO Unreviewed; 1943 AA.
AC A0A0D2JJF2;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=Z520_10965 {ECO:0000313|EMBL:KIX93322.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIX93322.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIX93322.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIX93322.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN848095; KIX93322.1; -; Genomic_DNA.
DR RefSeq; XP_016627445.1; XM_016781456.1.
DR STRING; 1442371.A0A0D2JJF2; -.
DR GeneID; 27716711; -.
DR VEuPathDB; FungiDB:Z520_10965; -.
DR OrthoDB; 25601at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR PANTHER; PTHR22834:SF20; NUCLEAR FUSION PROTEIN FUS2; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053411}.
FT DOMAIN 1170..1389
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1682..1808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1826..1846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1853..1872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..979
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1070
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1102
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1682..1703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1721..1746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1762..1799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1943 AA; 214251 MW; 20F7674F834B2890 CRC64;
MPSAVSNQSN YYTAHHRRQS SQSQTNLPDQ IRNAGPQLQS PNRSLVFLPS TAYSPSQPAT
QRSRTSSVSN LSRSTSRLDS VPNEDIQNDP REFYRQYQDP LGNSSLVALH QEAIRTDPIE
RAEEPPVTAR TSSFTTDDRM ARGAKSSGGS RKLSLNTQTL PNGTYDGGHA KSSGPMPNSL
KSRKASFKDL VARFDASPDD VPPLPTQQVS RPASRTASPM PYASVETSHS YHPQVKRLSS
RVSDASRRAG SALGFRAAAN DQSTHSRNAS SAGGLSQVAS NPEVPAAGRQ LLFGEVPSSA
ANLPAAPGYG IYNARRRRGS EGSPMHSPNP MFSTRRGHLH SPGPPISPSA MHSHTSGYAS
NGHPHSRPPH RRANSDVPGP ASKTFLHEDQ TPSISTRGSS HKHAADSSSK SNAQSRIPVS
TRHQRIASDS AAISPTGRPA IVPHQQLPFR ALESGLKASN PSPSGERKQH SPKRQPRSPV
QIKSPNNRGR PSTTASGEKS PSLRANIIAP PPKVSPPLRS SRPRLPVSSA TTAASRAKMA
EKFQTMAKQQ SDRKAFRRQR PPELSDIDLK ARRLKITQAL SRSREGQDLK GGNPENRDNS
ASRADTMTPS FEDSDTSDQR QETLEIPAVV VNEVPTDTSE ERAFYTGNGE VSQDQRAFTQ
TALKIVEGNV QHSADDVDSP TLGHAEPAFN GIPFSLNTHL QPARDEQEPQ SAVTEGTVAT
EATMIDAEPQ TDTSRLQTTG LSLRNQINAL RSQDSTPPLS SASQASGELS DHADQVSVHL
MLRDTTYLDD DEAAEKGYRP LVPLPQPEHA RPQSDGRNSW TSSIEDIPES EAGDEPPSVV
QPPPQFQHEA ETTHIESDSH SASDQLSLEG GSHGEHHASD AYTIVNKVLQ QQTPSGVVDQ
QLVDDIYHRI IQASPDLADA ENANEEKVQR LCLEELDEYT RQWDQLETSR PQSAESFHAE
AEPYSGHDTS EEQHDNTTKS PDIHGPSQVT PPAPPVPPSS YRTHHRYKSS LDSAEDWAET
SPSVGDWMQF ALRSPTEERQ PSALAHETFA DAGSGFSKTE NYQSVNPNEP EQPPHDFLPV
GAESNIPRPP SHSPPPPPLV KMPTIDQTAW SAPTGMRPAM PQTAPPARPL TALSQMSARS
SIDQQTTQSS LQDTRPSMDD QSPEQRRLNK RRHVLKELVD TEYTYERDMR VLCDIYKQTA
IAAINDEDIK ILFGNVDLVQ QFSKDFLAYL KQVVRPAYVM ERSDRRKDGN RTSTVQSSEA
SIDGIGELTD FERDELTRVG TAFEASIGDM EKVYTDYIRT RHAANKRLEA LQSSAAVREW
LKECSENSSD ITNAWSLDAL LVKPIQRITK YPLLLNQLLE ATPDTHPDVE FIRRAALEVT
EVNVRINEVK KHTELVDQVL NRKRKESDVR NGLTKAFGRR AEKLRQHVGI NEMHEDAEYT
KLKINYDNNI AHLFLVTKDC QGYIEEITKW VNRLVELAAA AEAWVDVGHT NHAQAESKLR
QFAIVVRGVH SIALPDHNEQ IIKRVVQPME KTATMLERFK SDSKGLIQKR DKRLLDYNQF
KNKKDRGEKI DKKMTERMEQ WEALNLEAKE RMKRLLRSTA DLVHACQANL IQLHLNWMAM
CRQKFSAAME IPLDKLETAD IVKDWQEDFD FQEATALSLS ICNGSLLAEA VNMVSFLTPG
STLMGDESPR QPSWNSAPKR SVSTSEDMPP LPLKDHYHRN SGGPMSSQSD DHTEWSSSTF
ANGRIRTGSA ASGRIPKTPE TGSRGVSASL HTVNSTNVSR PGTSPGLSAD SNQPAPRLSF
EAPSPSLGEL LTESPMAVRH ASSSTFYSAA PGPSQSQPHL PATSGASVFS SAMPMEETPE
PETTPAVPEP RREPGVLFTA ASVYEFNIDR SRQQGGFRYL TYVIGEIFDI IAEHGELWLA
INQDDPTREI GWIWNKHFAK LAE
//
