ID A0A0D2JKT5_9BACT Unreviewed; 611 AA.
AC A0A0D2JKT5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=J120_04710 {ECO:0000313|EMBL:KIX85003.1};
OS candidate division TM6 bacterium JCVI TM6SC1.
OC Bacteria; Candidatus Dependentiae; Vermiphilus.
OX NCBI_TaxID=1306947 {ECO:0000313|EMBL:KIX85003.1, ECO:0000313|Proteomes:UP000032214};
RN [1] {ECO:0000313|EMBL:KIX85003.1, ECO:0000313|Proteomes:UP000032214}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TM6SC1 {ECO:0000313|EMBL:KIX85003.1,
RC ECO:0000313|Proteomes:UP000032214};
RX PubMed=23754396; DOI=10.1073/pnas.1219809110;
RA McLean J.S., Lombardo M.J., Badger J.H., Edlund A., Novotny M.,
RA Yee-Greenbaum J., Vyahhi N., Hall A.P., Yang Y., Dupont C.L., Ziegler M.G.,
RA Chitsaz H., Allen A.E., Yooseph S., Tesler G., Pevzner P.A., Friedman R.M.,
RA Nealson K.H., Venter J.C., Lasken R.S.;
RT "Candidate phylum TM6 genome recovered from a hospital sink biofilm
RT provides genomic insights into this uncultivated phylum.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E2390-E2399(2013).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIX85003.1}.
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DR EMBL; ARQD01000004; KIX85003.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2JKT5; -.
DR STRING; 1306947.J120_04710; -.
DR eggNOG; COG0323; Bacteria.
DR Proteomes; UP000032214; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000032214}.
FT DOMAIN 209..327
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 424..568
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 611 AA; 68124 MW; B43EDC03687ECCFB CRC64;
MGKISILAPH EAQKIAAGEV VERPANVIKE LIENSLDAQS TSISIWVNQG AKSLLRVSDN
GSGMDEDDAV ACFNHHATSK ITTVNELETL STLGFRGEAL SSIASVAQVT LTTRTEHCLH
GHQIVCHSGT VISHQPAAAT VGTDISIANL FYNVPARRKF LKTAQTEWRQ IVHMIHAYCM
AYPHVHFKLY DQSGDLFLNC PPGTLQERIS FIWGHQEASS ALPVDYEDRS ITIKGVVCSA
HTLKYDRSNI YMFVNKRWIK NHALAKAIMQ GYSNTLLPGR YPVACILIEI DPGEVDINVH
PRKEEVQFAH PYKIQTHITN AVHNALEKSF MTKGVYAEKP VTSYTTTLAS SFSVPSWQPI
HPLNNAMSSP GIIQAHPVTT ITSMPDTNSI NSNTYSTLHE STPVSFQQTL IHSPLLQELP
ENKIVGQLLT MYIIVESSQG LLIVDQHAAH ERILYEKFRS KFGNAESAHL LFAKALTLHP
HDIELLEPHF QLLASCGVIV ERMGSDTIMI TGMPLHAQSY DGHELIKDML VWIASYKPLD
TMTLSDHLSF HIHSHMSCKA AIKAGDILSH DQMKKIVHDL QITSHNYSCP HGRPTSWTIT
EQELLRKFRR T
//
