ID A0A0D2JLJ9_9EURO Unreviewed; 397 AA.
AC A0A0D2JLJ9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=TFIIS N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51319};
GN ORFNames=Z520_10219 {ECO:0000313|EMBL:KIX94192.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIX94192.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIX94192.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIX94192.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor involved in RNA polymerase II
CC transcription regulation. May function in both SPT15/TBP post-
CC recruitment and recruitment steps of transcription.
CC {ECO:0000256|ARBA:ARBA00037349}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family.
CC {ECO:0000256|ARBA:ARBA00037992}.
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DR EMBL; KN848089; KIX94192.1; -; Genomic_DNA.
DR RefSeq; XP_016628315.1; XM_016780712.1.
DR AlphaFoldDB; A0A0D2JLJ9; -.
DR STRING; 1442371.A0A0D2JLJ9; -.
DR GeneID; 27715965; -.
DR VEuPathDB; FungiDB:Z520_10219; -.
DR OrthoDB; 12240at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000053411}.
FT DOMAIN 254..331
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 1..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..32
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 397 AA; 44786 MW; 1F077AAA36F55538 CRC64;
MSDFGDEGPP PDAEGLDRPD EHEDELDDLH DEFQDPQPEH DADTRPNLAD DSDDESLLSE
VDEAQFADFD PKAVEVAPDF DTLNKSIKVK KRKRAEGEEP APKKKKERRR DKKSRRAESE
ALSGGDQVEG KRRSHKPKAA NGETQRRAQV EINEDDLTPE ERRRRALDRA MDAAVKRSSG
KRMRKGEIDL EQAADAEIED LRNRMITAAE TDGELVRQGL PASQKLKMLP EVVSLLNRNT
YVQSILDPEM NLLEAVRFFL EPLTDGSLPA YNIQRELFAA LSKLPMNKET LISSGIGKVI
LFYRKSKKAE PAIKRQATKL MEDWSRPILG RSDDHTKKVW ATATYDPTKR REAAPAAIPK
PKSNLAPGER VSNRARVQTS HLNFHIVPQV SSTVPHR
//
