ID A0A0D2K3B9_9EURO Unreviewed; 671 AA.
AC A0A0D2K3B9;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Pyruvate carboxylase {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z520_04003 {ECO:0000313|EMBL:KIY00318.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIY00318.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIY00318.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIY00318.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR EMBL; KN848067; KIY00318.1; -; Genomic_DNA.
DR RefSeq; XP_016634440.1; XM_016774513.1.
DR AlphaFoldDB; A0A0D2K3B9; -.
DR STRING; 1442371.A0A0D2K3B9; -.
DR GeneID; 27709749; -.
DR VEuPathDB; FungiDB:Z520_04003; -.
DR OrthoDB; 2785982at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45007; CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED; 1.
DR PANTHER; PTHR45007:SF1; CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000053411}.
FT DOMAIN 7..455
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 128..323
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 574..656
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 671 AA; 72912 MW; 9BA8D14052191144 CRC64;
MPPPQRPISR ILVANRGEIA IRILQSCHEL APQPPTTFAI YTDNDSTHIS LGRPHHAIKA
AFGPASYMNI DYLIGVVKEH KIDAVHPGYG FLSESAEFSR RMWEEAGCVV VGPGWEVLER
TGDKLMAKAL ASECGVPVLK AMERPTGSVE DVRRFAASVG YPLMIKAVDG GGGRGIRLVK
SEDALDNAVQ RCVAESPSRL VFAEQAAVEG YKHIEVQIVG DGKGGVTHLW ERDCSVQRRF
QKIVELAPAP VQNRKVIAQV IDSAVRMATQ LKYLGLGTWE YLVNVQQEKF FFLEINPRLQ
VEHTITECIT GVDLVKQQLL LAQGLQTRLG GSHDANKAPP SASIQLRLCA EDPTAGFSLS
IGKVSDVQFP SGNGVRVDSH LSRGGVVGSD FDNMMAKVIV TASTWEECVG KARRALEETK
IVGVKSNLNL LKAILTHERF AAGDADTSWL ERNLDQLVAL GEQLGSITEI RESSLPALSL
SSSNTPGSAV GGAGASTLFR KGDAWTLVLE NSGEKSSSSV KPPAHHLSIS RVTRNEFPAA
LIADISYTIP GARTHSYKMT LNSTTSSADA AASTHRRGDP SKKTHIVLPM SGKLVEVLVD
EGDEVRENEV IAFVKQMKME LEVRSPRAGK VKWVIEMENE EEGDDVAEGV LLVELEDEED
SAKKPEVRSR L
//
