ID A0A0D2KAQ1_9EURO Unreviewed; 1087 AA.
AC A0A0D2KAQ1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752};
DE EC=3.2.1.24 {ECO:0000256|ARBA:ARBA00012752};
GN ORFNames=Z520_10746 {ECO:0000313|EMBL:KIX93568.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIX93568.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIX93568.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIX93568.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; KN848093; KIX93568.1; -; Genomic_DNA.
DR RefSeq; XP_016627691.1; XM_016781238.1.
DR AlphaFoldDB; A0A0D2KAQ1; -.
DR STRING; 1442371.A0A0D2KAQ1; -.
DR GeneID; 27716492; -.
DR VEuPathDB; FungiDB:Z520_10746; -.
DR OrthoDB; 2786490at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10812; GH38N_AMII_ScAms1_like; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053411}.
FT DOMAIN 556..635
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1087 AA; 123296 MW; 43DFF605CE984A34 CRC64;
MGGETSSRAT SSYPRLSAHP VGQKIQSIYT DRLRQFTSGG QYEKENLLDK LYHNVCDDED
HVKLSVYSPP NLSRPTFHDA TSHTFRPTHR GESFGPAWAT HWFKIQLTVP KHMRDGEHLE
FHWDANNEGM VWTEDGNPLQ GLTGGGDRTE WILPTSWRDG KEHIFYIEMA CNGMFGNAPG
GDSIQPPDPN KYYTLWKAQI VDVNLAARHL YVDFWIIGDA AREFPGDSWE KHEALQICNQ
IMDVFIAGNG SAASIQKGRE IAQKYIGKNV DSAKVYDSDE KSIVYGIGHC HIDTCWLWPW
AETKRKVARS WSNQCDLMDR YPEHRFAVSQ AQQYKWLKMY YPYVFDRVKA KVKEGRFHPI
GGSWVEHDTN MPSGESLVRQ FLYGQRFFES NFGERCQTFW LPDTFGYSAQ LPQICRLAGM
TRFFTQKLSW NNINNFPHTT FNWVSLDGSQ VICHMAPSET YTADAHFGDV RRSVTQHKSM
DQDNTSLLVF GKGDGGGGPT WSMLEKLRRC RGLSDTVGLL PRVHMGKSVD DFYANLEKKV
ADGTELVTWY GELYFELHRG TYTTQANNKL NNRKQEIMLH DVEYLATLAS LKSKSYKYPK
KEIDEMWENV LLCQFHDCLP GSSIEMCYDD SDELYAHNAK LGEKVKEEAL TVLGLSQHLK
ANAELAAVNT APWKRSELVK IPQANAKSQE QKYTYISGGP GICKTHAASA IQSTASIEEV
RKGVFVLKNS MFQAEVEAGC ITSLIDLRAN REVIAKGGKG NQLVMFDDKP LYWQAWDVEV
FHLDSRKELK SEASEIVEHG PYRVSVATKT QVSKDSWIKT TISLDACDSQ TQTGYLLVEA
EVEWHENMKF LKVEFPVDVV NTEANYETQY GIIRRPTHYN TSWDMAKFEV CCHKFADLSE
ANYGVSILND SKYGFATCGN LMRLSLLRAP KAPDAHADMG RHHIKWAIMP HQGSMSSDTV
RAAYNLNHPM TLVSLVDDKP PKELFNAVSV TGAPSLILDC VKRGEDDEDV SRGELTQRKG
QSVILRIYES MGGKSRGVIE TTLPVKKVYE TNVLEDDGKQ LDMSGKNKIS IPIELRAFEV
KTFRLQL
//
