ID A0A0D2KD11_9EURO Unreviewed; 340 AA.
AC A0A0D2KD11;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Dihydrodipicolinate synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z520_02642 {ECO:0000313|EMBL:KIY01090.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIY01090.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIY01090.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIY01090.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
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DR EMBL; KN848065; KIY01090.1; -; Genomic_DNA.
DR RefSeq; XP_016635212.1; XM_016773155.1.
DR AlphaFoldDB; A0A0D2KD11; -.
DR STRING; 1442371.A0A0D2KD11; -.
DR GeneID; 27708388; -.
DR VEuPathDB; FungiDB:Z520_02642; -.
DR OrthoDB; 1780992at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF72; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 2.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000053411}.
FT ACT_SITE 157
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 187
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 240
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 340 AA; 37393 MW; 916CC05A4982AFD4 CRC64;
MRELRPGLYG PLPTFFDDDQ ELDLASYREH LAGSLGEGAH LVGWFLFCRR PDLLRPQIFN
SAGYIHQDPS ERRTLIEVTR QTLDDLSLTS TPIVAGVGGL STRETIRLCR DAAAAGADAG
LVILPAYYAA SLNSDQEQIV KYYVDICEAS PIPLFLYNFP TNAAGLDMSS EVIEKIMRAA
PNLCGVKLTC GGSIGKLVRL KAAQDGFQTT MPTRRFPFLL LDGLIGDLTA WKACGGHGTV
SGIPNFAPRA SVRLWELLNT SSPTHEEVSE RDKLQAVLSR ADAIAVHAGI RAMKFVLHQV
HGYGKAPRRP LLPLNEDEGQ LFLASLSELL ETEREYQKRE
//
