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Database: UniProt
Entry: A0A0D2LWN0_9AGAR
LinkDB: A0A0D2LWN0_9AGAR
Original site: A0A0D2LWN0_9AGAR 
ID   A0A0D2LWN0_9AGAR        Unreviewed;      1079 AA.
AC   A0A0D2LWN0;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   05-JUN-2019, entry version 24.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=HYPSUDRAFT_172822 {ECO:0000313|EMBL:KJA15253.1};
OS   Hypholoma sublateritium FD-334 SS-4.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Agaricales; Strophariaceae;
OC   Hypholoma.
OX   NCBI_TaxID=945553 {ECO:0000313|EMBL:KJA15253.1, ECO:0000313|Proteomes:UP000054270};
RN   [1] {ECO:0000313|EMBL:KJA15253.1, ECO:0000313|Proteomes:UP000054270}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FD-334 SS-4 {ECO:0000313|EMBL:KJA15253.1,
RC   ECO:0000313|Proteomes:UP000054270};
RG   DOE Joint Genome Institute;
RA   Kohler A., Kuo A., Nagy L.G., Floudas D., Copeland A., Barry K.W.,
RA   Cichocki N., Veneault-Fourrey C., LaButti K., Lindquist E.A.,
RA   Lipzen A., Lundell T., Morin E., Murat C., Riley R., Ohm R., Sun H.,
RA   Tunlid A., Henrissat B., Grigoriev I.V., Hibbett D.S., Martin F.,
RA   Consortium M.G.;
RT   "Evolutionary Origins and Diversification of the Mycorrhizal
RT   Mutualists.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KN817650; KJA15253.1; -; Genomic_DNA.
DR   EnsemblFungi; KJA15253; KJA15253; HYPSUDRAFT_172822.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000054270; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005657; C:replication fork; IEA:EnsemblFungi.
DR   GO; GO:0008296; F:3'-5'-exodeoxyribonuclease activity; IEA:EnsemblFungi.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0043137; P:DNA replication, removal of RNA primer; IEA:EnsemblFungi.
DR   GO; GO:0045005; P:DNA-dependent DNA replication maintenance of fidelity; IEA:EnsemblFungi.
DR   GO; GO:0006278; P:RNA-dependent DNA biosynthetic process; IEA:EnsemblFungi.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054270};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054270};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      113    452       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      516    947       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      984   1057       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     43       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0D2LWN0}.
FT   REGION       59     78       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0D2LWN0}.
FT   COILED      637    657       {ECO:0000256|SAM:Coils}.
FT   COILED     1057   1077       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1079 AA;  121262 MW;  F96B088EEBA5FE9E CRC64;
     MAEKGKENVS LVRTSTETDV IPPPAAKKRK LGPTQSFGSQ PIQEQPSFIE VLARLKEEGA
     NGKSEAEGGA DQWARPPLPR IDEKRDSIIF QQIDVETASG YDGSTILRMF GVTEDGHSVL
     ANITDFKPYF YVAIPRGFTD ADLAPFREYL DSCLDDGGKV IGTEKVMKKS LWGYRGEDNV
     PFLKIILSEP RSVPKIRGMF DRGECNYQGL FDGEIPTFES NMVFTLRFMI DTKVVGMNWI
     EVPAGKYKIT PDAQKRSTCQ LEISVRFDSF ISHAPEGNWS KIAPLRILSF DIECAGRKGI
     FPEASVDPVI QIANMVSRQG ESKPFVRNIF TLNTCSNIVG SQVISFNDES DMLHAWRDFV
     EKADPDVVIG YNIGNFDFPY LMDRAKALKA TRFPYLGRMK GSKTDTKNTH FSSKAYGQRD
     SKETTLDGRL QLDLLQFMQR EHKLRSYTLN SVCAQFLGEQ KEDVHHSVIT ELQNGTPESR
     RRLAVYCLKD AYLPQRLLDK LMCLVNYIEM SRVTGVPFNF LLSRGQSIKV LSQLYRKANE
     VGYLVPAGKG EGSDEQYEGA TVIEPKKGYY DVPIATLDFA SLYPSIMMAH NLCYTTLLDR
     ATVDRLKLVK DQDYIQTPNN DLFATSSKRK GLLPIILEDL ISARKRAKAD LKKETDSFKK
     AVLDGRQLAL KISANSVYGF TGATIGKLAC LPISSSVTAY GRQMIEKTKR EVEAEYCIAN
     GHSHDAEIIY GDTDSVMVRF GPTDLAQVMD LGREAAAFVT AKFIKPINLE FEKVYYPYLL
     ISKKRYAGLY WTKPEKYDKM DAKGIETVRR DNCRLVSTVI GTCLHKMLID RDVKGAEDFT
     KRIISDLLQN KVDMSQLVIT KALSKTDYAG KQAHVELAER MKQRDAGSAP ALGDRVAYVI
     TKGIKGAAAW EKSEDPLYVL ENNMPIDTKY YLENQLSKPL LRIFEPILGD KATSLLSGDH
     TRSIQIATPT VGGLMKFAVK TVTCLGCKTP LRGKELSGAL CKNCKPRMQE LYQKQITTTS
     ALQVRFSRLW TQCQRCQGSL HQDVLCTSKD CPIFYMRKKA QKDVEDANKV LERFDGDDW
//
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