ID A0A0D2NN71_GOSRA Unreviewed; 542 AA.
AC A0A0D2NN71;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN ORFNames=B456_006G075200 {ECO:0000313|EMBL:KJB34607.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB34607.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB34607.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out);
CC Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00033682};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + Na(+)(in) = H(+)(in) + Na(+)(out);
CC Xref=Rhea:RHEA:29419, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101;
CC Evidence={ECO:0000256|ARBA:ARBA00033620};
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
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DR EMBL; CM001745; KJB34607.1; -; Genomic_DNA.
DR EMBL; CM001745; KJB34608.1; -; Genomic_DNA.
DR EMBL; CM001745; KJB34609.1; -; Genomic_DNA.
DR RefSeq; XP_012484498.1; XM_012629044.1.
DR RefSeq; XP_012484499.1; XM_012629045.1.
DR RefSeq; XP_012484500.1; XM_012629046.1.
DR RefSeq; XP_012484501.1; XM_012629047.1.
DR RefSeq; XP_012484502.1; XM_012629048.1.
DR RefSeq; XP_012484503.1; XM_012629049.1.
DR RefSeq; XP_012484504.1; XM_012629050.1.
DR AlphaFoldDB; A0A0D2NN71; -.
DR EnsemblPlants; KJB34607; KJB34607; B456_006G075200.
DR EnsemblPlants; KJB34608; KJB34608; B456_006G075200.
DR EnsemblPlants; KJB34609; KJB34609; B456_006G075200.
DR GeneID; 105798840; -.
DR Gramene; KJB34607; KJB34607; B456_006G075200.
DR Gramene; KJB34608; KJB34608; B456_006G075200.
DR Gramene; KJB34609; KJB34609; B456_006G075200.
DR KEGG; gra:105798840; -.
DR eggNOG; KOG1965; Eukaryota.
DR OMA; IHHYWRS; -.
DR OrthoDB; 5490606at2759; -.
DR Proteomes; UP000032304; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF159; SODIUM_HYDROGEN EXCHANGER 3; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT TRANSMEM 23..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..444
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 542 AA; 60016 MW; B4C5BA37582C40E9 CRC64;
MTIGIISFAL ANSETTFASD HAPIVSINLF VALLCGCIVI GHLLEENRWM NESITALAIG
VCTGVIILLT TGGKSSRLLV FSEDLFFIYL LPPIIFNAGF QVKKKQFFRN FMTIMLFGAV
GTLISFCVIS IGAIHFFKKM NIGDLTLGDY LAIGAIFSAT DSVCTLQVLN QDETPLLYSL
VFGEGVVNDA TSVVLFNAIQ TFDLSHINST MALQYIGNFL YLFILSTLLG VLAGLLSAYI
IRKLYFGRHS TDREVALMML MAYLSYMLAE LFSFSAILTV FFCGIVMSHY TWHNVTESSR
VTTKHAFATL SFVSEIFIFL YVGMDALDIE KWRVISDSPG TLVGVSGILL GLILVGRAAF
VFPLSFISNL TRKAPHEKVD FKQQVTVWWA GLMRGAVSMA LAYNQFTSLG HTQLRGNAMM
ITSTISVVLF STVVFGLMTK PLVRLLLPSP KHLTRTLSSE PSTPKSFIVP LIGNEGEPEA
DQNNRNARRP TSLRMLLTTP SNTVHYYWRK FDDAFMRPVF GGRGFVPFVP GSPTEQNGHQ
WQ
//
