ID A0A0D2PX24_GOSRA Unreviewed; 1700 AA.
AC A0A0D2PX24;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA repair protein UVH3 {ECO:0008006|Google:ProtNLM};
GN ORFNames=B456_001G260400 {ECO:0000313|EMBL:KJB11469.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB11469.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB11469.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
CC {ECO:0000256|ARBA:ARBA00005283}.
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DR EMBL; CM001740; KJB11469.1; -; Genomic_DNA.
DR STRING; 29730.A0A0D2PX24; -.
DR EnsemblPlants; KJB11469; KJB11469; B456_001G260400.
DR Gramene; KJB11469; KJB11469; B456_001G260400.
DR eggNOG; KOG2520; Eukaryota.
DR OMA; PNSMDFS; -.
DR Proteomes; UP000032304; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd09904; H3TH_XPG; 1.
DR CDD; cd09868; PIN_XPG_RAD2; 2.
DR Gene3D; 6.10.250.1630; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 2.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR001044; XPG/Rad2_eukaryotes.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR16171:SF7; DNA EXCISION REPAIR PROTEIN ERCC-5; 1.
DR PANTHER; PTHR16171; DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED; 1.
DR Pfam; PF14377; UBM; 2.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR PRINTS; PR00066; XRODRMPGMNTG.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00841; XPG_1; 1.
DR PROSITE; PS00842; XPG_2; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..98
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 1003..1072
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 129..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1624..1700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..423
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..613
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 666..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..718
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1460..1491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1674..1688
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1700 AA; 189037 MW; 1E80A3F6ACC5336C CRC64;
MGVHGLWELL APVGRRVSVE TLAGKKLAID ASIWMVQFMK AMRDEKGEMI RNAHLLGFFR
RICKLLYLKT KPVFVFDGAT PILKRRTVIA RRRQRENAQA KIRKTAEKLL LNQLKQMRLK
ELAKDLDNQR KMQKNNNKDK GKMVSSDNQS DTNFVGCNAN VELTKEGDVK LKEKLEVPSI
AKDGGHNEDE DEDEDEVIIL PDIDGNIDPD VLAALPQSMQ RQLLKQILLN DLNQSNKERS
GTEHDAMTST SYSQEKLDEM LAASLATQED SNLANASTSV AAIPSEDDGD EDEEMILPAM
HGNVDPAVLA ALPPSLQLDL LGQMRERLMA ENRQKYQKVK KAPEKFSELQ IQSYLKTVAF
RREIDEVQRA AAGRGVAGVQ TSRIASEANR EFIFSSSFTG DKQALTSARK EIDEDKQQER
HSDHPSGFLG SVKSSCKSNV AAESVPDEST SAPDEDVGTY VDATGRIRVS RVRGMGIRMT
RDLQRNLDLM KEIEKERTNL NKGVNVKSVP DKSKIDASKS VSNGNQFVET SHDDNGESVN
VNESNQQSAF ETESCMEITF EDDGKTEYFD DDDIFARLAA GEPVTLPSPE EKSLRKQPSG
SDSDFEWEEG VVEGKWDGVT PGMNAEHNLL NKESNITDDS EVEWEEEPSD APKSSSGPVE
SGRMLSKGYW EEESDLQEAI RRSLTDVGVE KSNSFPSDVI ESKNLGENLD EDFGSLHEKG
DTGASSFPGD AVNWQNKSCE NLDRPRKPCT VNEPSISETF NSPESPSPVH NSDKNMTILS
KFSERSDGSH SEQSRHNETA EFVATLEKEV DFPTGKHLDV SKEVDGLSTI SDSWFKDNSH
SFDAAHGDIP DTIQVDKKTG SEDEPSNLVS DNKSSIEAEI LDQDKKIDFE AKPSQQSVDT
VNLSIPTVQS SANKVISDLH IEQELSGDIT YENCVNKAEQ HTDMSTIKGN DNEEIKFSKA
SLDEELLILD QECINMVDEQ RKLERNAESV SSEMFAECQE LLQMFGLPYI IAPMEAEAQC
AYMELTNLVD GVVTDDSDVF LFGARSVYKN IFDDRKYVET YFMQDIEKEL GLTREKLMRM
ALLLGSDYTE GVSGIGIVNA IEVVNAFPEE DGLHKFREWI ESPDPTILGK LNVQEGSSAR
KRGPKSTEKD VNGTKTSTRG SESNNGTSSL DQNSFQADKN MQSTDCTDDI KQIFMDKHRN
VSKNWHIPSS FPSEAVISAY SLPQVDKSTE PFTWGRPDLF VLRKLCWEKF GWGSQKSDEL
LLPVLRESEK RETQLRMEAF YTFNERFAKI RSKRIKKAVK GITGNQSSEL IDDGMQQVSK
SRRKRRASPV QSGDDKSGEP SNKKEDIASR CQSKSTDKSV PKTSRKRQSS GKDVSFEMRT
PEPQLQTLRR RETNKQSAGN GRGRGGGEGR RRKGSSGFQQ FETSSSGGDS GNVNQEVDGE
KLDQPREVRR SMHTRNPVNY TVKDLEDEGG LSHKESSGED AMEKEAGEDV KEKIQCEARE
PSLDNIYGDY LETGGGFCMD ERGTDLPDAN QDVDLETEPT NDYLKMGGGF YMEGDIDQPD
TSQDVNPFSE TGSANDYLKM GGGFCMEESE TIGNPDAGNY EDPVQATESS NCFAFMDKAD
DNIDSAEPSV NAEGSLLDKL QNGGKTPDEA NDALNLNHRN AANKDDSKES ASLPEASDVG
TTFISGLSAM PSLKRKRRRR
//
