ID A0A0D2QBR3_GOSRA Unreviewed; 1111 AA.
AC A0A0D2QBR3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=B456_009G081400 {ECO:0000313|EMBL:KJB55542.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB55542.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB55542.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR EMBL; CM001748; KJB55542.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2QBR3; -.
DR EnsemblPlants; KJB55542; KJB55542; B456_009G081400.
DR Gramene; KJB55542; KJB55542; B456_009G081400.
DR Proteomes; UP000032304; Chromosome 9.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00121; MATH; 1.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF929; UBIQUITINYL HYDROLASE 1; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 53..178
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 198..516
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT COILED 525..556
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1111 AA; 130384 MW; 5598836B9C4E61DE CRC64;
MTVMTPSPID QQEDEEMLVP HSDLTDNHQP MEVVSQAENA NTVENQPVED PPSSRFTWKI
DNFSRLNTKK HYSDVFVVGG YKWRILIFPK GNNVDHLSMY LDVADSASLP YGWSRYAQFS
LAVVNQIHSK YSIRKDTQHQ FNARESDWGF TSFMPLGELY DPCRGYLVND TFVVEAEVVV
RKIVDYWAYD SKKETGYVGL KNQGATCYMN SLLQTLYHIP YFRKAVYHMP TTENDMPSGS
IPLALQSLFY KLQYSDSSVA TKELTKSFGW DTYDSFMQHD VQELNRVLCE KLEDKMKGTV
VEGTIQQLFE GHHMNYIECI NVDYKSTRKE SFYDLQLDVK GCRDVYASFD KYVEVERLEG
DNKYQAEQYG LQDAKKGVLF IDFPPVLQLQ LKRFEYDFMR DTMVKINDRY EFPLQLDLDR
DDGKYLSPEA DRSVRNLYTL HSGGVHGGHY YAYIRPTLSD QWYKFDDERV TKEDMKKALE
EQYGGEELPQ TNPGFNNTPF KFTKYSNAYM LVYIRESDKD KIICNVDEKD IAEHLRERLK
KEQEEKEHKK KEKAEAHLYT IIKVARDDDL AEQIGKGICF DLVDHDKVRS FHIQKQMPFN
VFKEEVAREF GIPVQFQRFW LWAKRQNHTY RPNRPLTPLE ETQSVGALKE VSNKVHNAEL
KLFLEVELGL DLRPIAPPYK TKEDILLFFK HYDPEKEELR YVGRLFVKSA GKPTEILSRL
NKMAGYAPDE DINLYEEIKF EPSVMCEPID KKITFRASQL EDGDIVCFQK PLPVESTNQY
RYPDVPSFLE YVHNRQVVHF RSLEKPKEDD FCLEMSRLYT YDDVVERVAQ QLGLDNPSKI
RLTSHNCYSQ QPKPQPIKYR GVDHLSDMLF HYNQTSDILY FEVLDIPLPE LQGLKTLKVA
FHHATKDEVV IHTIRLPKQS TVGDVINDLK TKVELSHPDA ELRLLEVFYN KIYKIFPPNE
KIENINDQYW TLRAEEIPEE EKNLGPNDRL IHVYHFTKET AQNQMQILNF GEPFFLVIHE
GETLAEIKVR IQRKLQVPDE EFAKWKFAFL SLGRPEYLQD SDIVSSRFQR RDVYGAWEQY
LGLEHSDNIP KRAYAINQNR HTFEKPVKIY N
//
