ID A0A0D2QEN5_GOSRA Unreviewed; 746 AA.
AC A0A0D2QEN5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000259|PROSITE:PS50042};
GN ORFNames=B456_009G123300 {ECO:0000313|EMBL:KJB56512.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB56512.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB56512.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- SUBUNIT: Homotetramer or heterotetramer.
CC {ECO:0000256|ARBA:ARBA00011102}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel (TC
CC 1.A.1.5) family. {ECO:0000256|ARBA:ARBA00010486}.
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DR EMBL; CM001748; KJB56512.1; -; Genomic_DNA.
DR RefSeq; XP_012448061.1; XM_012592607.1.
DR AlphaFoldDB; A0A0D2QEN5; -.
DR STRING; 29730.A0A0D2QEN5; -.
DR EnsemblPlants; KJB56512; KJB56512; B456_009G123300.
DR GeneID; 105771195; -.
DR Gramene; KJB56512; KJB56512; B456_009G123300.
DR KEGG; gra:105771195; -.
DR eggNOG; KOG0498; Eukaryota.
DR OrthoDB; 3076617at2759; -.
DR Proteomes; UP000032304; Chromosome 9.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR GO; GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45651; CYCLIC NUCLEOTIDE-GATED ION CHANNEL 15-RELATED-RELATED; 1.
DR PANTHER; PTHR45651:SF23; CYCLIC NUCLEOTIDE-GATED ION CHANNEL 8-RELATED; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW cGMP {ECO:0000256|ARBA:ARBA00022535};
KW cGMP-binding {ECO:0000256|ARBA:ARBA00022992};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022992};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 508..592
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 671..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 85609 MW; DAD61AD7E2F53727 CRC64;
MFGGAYKSQI IGGQKEKFVR LDDLDSPVSM ASGTGGMKKG GFNVEGYKYS GPGKKKASKK
SFNIGMMKGP EGLLTLGRNL RSEVTRVVFP EDLKVSDKMI FDPQDKSILL WNRFFVVSCI
LSVSVDPLFF YLPIFNGRAH CLGIDVRLGV TTTTIRTIID AFYLIRMGLQ FRTAYIAPSS
RVFGRGELVI DPAQIATRYL SRYFIVDFLS VLPLPQMVVW KYLHKSKGSE VWATKQALLV
IVFVQYIPRF VRFIPLTSEL KKTAGTFADS AWVGAAYYLL WYILASHIAG AFWYLLAVER
KDTCWRIACE QSGKCNIDFL YCGNKHMQGF AAWRRVRDKE LDGKCGLQDD DSPFNYGIYT
RAIESEIVSS NVFFSKFCYC LWWGLQNLST LGQGLETSTY PGEVLFSIAI AIFGLILFAL
LIGNMQTYLQ SLTVRLEEMR IKRRDSEQWM HHRALPEDLK ERVRRYDQYK WLETRGVDEE
NLVQSLPKDL RRDIKRHLCL NLVRRVPLFA NMDERLLDAI CERLKPSLYT EHTYIVREGD
PVNEMLFVIR GRLESVTTDG GRSGFFNRGL LKEGDFCGEE LLTWALDPKA GSNLPLSTRT
VMALTEVEAF ALEAEELKFV SSQFRRLHSR QVQHTFRFYS QQWRTWAACF IQTAWRKYAK
RKHAELRRKE EEEELDYYDD DDDDDQQALI GQTGSSTEQH SIRATIFASR FAANLRGHRG
RGSTSSKSLL KVSKPTDPDF TDLDNR
//
