ID A0A0D2SLK2_GOSRA Unreviewed; 328 AA.
AC A0A0D2SLK2;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KJB84142.1};
GN ORFNames=B456_N008000 {ECO:0000313|EMBL:KJB84142.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB84142.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB84142.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-
CC carboxylate + H(+) = (S)-allantoin + CO2; Xref=Rhea:RHEA:26301,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:58639; EC=4.1.1.97;
CC Evidence={ECO:0000256|ARBA:ARBA00001163};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-
CC dihydro-1H-imidazole-5-carboxylate + H(+); Xref=Rhea:RHEA:23736,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18072,
CC ChEBI:CHEBI:58639; EC=3.5.2.17;
CC Evidence={ECO:0000256|ARBA:ARBA00001043};
CC -!- PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from
CC urate: step 3/3. {ECO:0000256|ARBA:ARBA00004754}.
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DR EMBL; KB204120; KJB84142.1; -; Genomic_DNA.
DR EMBL; KB204120; KJB84144.1; -; Genomic_DNA.
DR EMBL; KB204120; KJB84146.1; -; Genomic_DNA.
DR RefSeq; XP_012466122.1; XM_012610668.1.
DR RefSeq; XP_012466123.1; XM_012610669.1.
DR AlphaFoldDB; A0A0D2SLK2; -.
DR STRING; 29730.A0A0D2SLK2; -.
DR EnsemblPlants; KJB84142; KJB84142; B456_N008000.
DR EnsemblPlants; KJB84144; KJB84144; B456_N008000.
DR EnsemblPlants; KJB84146; KJB84146; B456_N008000.
DR GeneID; 105784728; -.
DR Gramene; KJB84142; KJB84142; B456_N008000.
DR Gramene; KJB84144; KJB84144; B456_N008000.
DR Gramene; KJB84146; KJB84146; B456_N008000.
DR KEGG; gra:105784728; -.
DR eggNOG; KOG3006; Eukaryota.
DR OrthoDB; 324942at2759; -.
DR Proteomes; UP000032304; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblPlants.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:EnsemblPlants.
DR GO; GO:0005777; C:peroxisome; IEA:EnsemblPlants.
DR GO; GO:0051997; F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity; IEA:EnsemblPlants.
DR GO; GO:0033971; F:hydroxyisourate hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblPlants.
DR GO; GO:0019428; P:allantoin biosynthetic process; IEA:EnsemblPlants.
DR GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IEA:EnsemblPlants.
DR GO; GO:0009631; P:cold acclimation; IEA:EnsemblPlants.
DR GO; GO:0051262; P:protein tetramerization; IEA:EnsemblPlants.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR GO; GO:1900457; P:regulation of brassinosteroid mediated signaling pathway; IEA:EnsemblPlants.
DR GO; GO:0001560; P:regulation of cell growth by extracellular stimulus; IEA:EnsemblPlants.
DR GO; GO:1900140; P:regulation of seedling development; IEA:EnsemblPlants.
DR CDD; cd05822; TLP_HIUase; 1.
DR Gene3D; 1.10.3330.10; Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 1.
DR Gene3D; 2.60.40.180; Transthyretin/hydroxyisourate hydrolase domain; 1.
DR InterPro; IPR014306; Hydroxyisourate_hydrolase.
DR InterPro; IPR018020; OHCU_decarboxylase.
DR InterPro; IPR036778; OHCU_decarboxylase_sf.
DR InterPro; IPR023418; Thyroxine_BS.
DR InterPro; IPR000895; Transthyretin/HIU_hydrolase.
DR InterPro; IPR023416; Transthyretin/HIU_hydrolase_d.
DR InterPro; IPR036817; Transthyretin/HIU_hydrolase_sf.
DR InterPro; IPR023419; Transthyretin_CS.
DR NCBIfam; TIGR02962; hdxy_isourate; 1.
DR PANTHER; PTHR43466; 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR43466:SF1; 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED; 1.
DR Pfam; PF09349; OHCU_decarbox; 1.
DR Pfam; PF00576; Transthyretin; 1.
DR PRINTS; PR00189; TRNSTHYRETIN.
DR SUPFAM; SSF49472; Transthyretin (synonym: prealbumin); 1.
DR SUPFAM; SSF158694; UraD-Like; 1.
DR PROSITE; PS00768; TRANSTHYRETIN_1; 1.
DR PROSITE; PS00769; TRANSTHYRETIN_2; 1.
PE 4: Predicted;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304}.
FT DOMAIN 12..155
FT /note="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /evidence="ECO:0000259|Pfam:PF09349"
FT DOMAIN 209..327
FT /note="Transthyretin/hydroxyisourate hydrolase"
FT /evidence="ECO:0000259|Pfam:PF00576"
FT BINDING 212
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR600895-51"
FT BINDING 262
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR600895-51"
FT BINDING 325
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR600895-51"
SQ SEQUENCE 328 AA; 35956 MW; B76E35AB57E29ADC CRC64;
MEEIKVDEKE ALACCGSSQF AKQMALASPF PSVDHAISVA KDIWFDKVDV IGWLEAFAAH
PQIGESPSSH TKSAQWSKGE QSTALATATD SGLQELSDWN ARYRQKFGHV FLICASGRSA
AEILGELKKR YSNRPIHELE IASQEQMKIT ELRLRKLFSA KAKADSTGSQ YSTAVAKERV
GIIGQHLTAP LEGFPAKAPQ VQARTRPPIT THVLDVSRGS PAAGIEVRLE MWKSSQPRPS
FGGTDIGGWV LEGCSTTDRD GRSGQLMSIV DALSPGVYRI SFNTGKYNPG GFFPYVSIVF
EIKDTQKFEH FHVPLLLSPF SFSTYRGS
//
