ID A0A0D2U6A7_GOSRA Unreviewed; 804 AA.
AC A0A0D2U6A7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=B456_010G047800 {ECO:0000313|EMBL:KJB64404.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB64404.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB64404.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- FUNCTION: May be involved in the transport of sterols.
CC {ECO:0000256|ARBA:ARBA00003361}.
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DR EMBL; CM001749; KJB64404.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2U6A7; -.
DR EnsemblPlants; KJB64404; KJB64404; B456_010G047800.
DR Gramene; KJB64404; KJB64404; B456_010G047800.
DR Proteomes; UP000032304; Chromosome 10.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13294; PH_ORP_plant; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF96; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1A-RELATED; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15413; PH_11; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 106..236
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 33..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..368
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 804 AA; 92013 MW; F9D9177321232F03 CRC64;
MHPFCCVSTV SEHSPVKPLA DQVISMRPPT VTTVTTTTSS SAPTTRSNSA RSTAQIQCQS
NQNHHRSNSV DLNRVVQRNG IPSGREATTA TAPPPQVDVK INDIVGNGIS GVLYKWVNYG
KGWRPRWFVL QDGVLSYYKI HGPDKIVVSQ ETEKGSKVIG EESHRIISRH RNSISHNSAT
RRKPFGEVHL KVSSIRESRS DDKRFSIFTG TKRLHLRAET RDDRVAWMEA LQAVKDMFPR
MSNSELMAPT DNVVVSTEKL RKRLMLEGIS ESAIQDSEQI MKSEFAELQK QLVLLKQKQW
LLIDTLRQLE TEKVDLENTV VDESQNKLND QGASSMIRQD KSSEGSVTDT DEDNERVDAA
EEETDEDEHN FFDTRDFLSS SSFKSNGSDF RTSSFSSDDG LNGFDSEDDI DPYIKSVGSN
FPYIKRRKKL PDPVEREKGV SLWSMIKDNI GKDLTKVCLP VYFNEPLSSL QKCFEDLEYS
YLLDRAYEWG KRGNNLMRIL NVAAFAVSGY SSTEGRICKP FNPLLGETYE ADFPDKGLRF
FSEKGTGWKL WGDSNLKSKF WGRSIQLDPV GVLTLEFEDG EVFQWSKVTT SIYNLILGKL
YCDHYGTMRI EGNREYSCKL KFKEQSIIDR NPHQVHGIVQ DRNGRTTASL LGKWDESMHY
VNGDYSAKGK GQESLSESHL LWRRSKPPKY PTRYNLTRFA ITLNELTPGL KEKLPPTDSR
LRPDQRYLEN GEYEMANSEK LRLEQRQRQA RKMQESGWKP RWFAKDKNSG TYHYIGGYWE
AREKRKWDSC PDIFGQIPCD QILE
//