ID A0A0D2UKS4_CAPO3 Unreviewed; 945 AA.
AC A0A0D2UKS4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=RAS p21 protein activator 3 {ECO:0000313|EMBL:KJE95651.1};
GN ORFNames=CAOG_006078 {ECO:0000313|EMBL:KJE95651.1};
OS Capsaspora owczarzaki (strain ATCC 30864).
OC Eukaryota; Filasterea; Capsaspora.
OX NCBI_TaxID=595528 {ECO:0000313|EMBL:KJE95651.1, ECO:0000313|Proteomes:UP000008743};
RN [1] {ECO:0000313|Proteomes:UP000008743}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 30864 {ECO:0000313|Proteomes:UP000008743};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capsaspora owczarzaki ATCC 30864.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE346369; KJE95651.1; -; Genomic_DNA.
DR RefSeq; XP_004345668.2; XM_004345618.2.
DR AlphaFoldDB; A0A0D2UKS4; -.
DR STRING; 595528.A0A0D2UKS4; -.
DR EnsemblProtists; KJE95651; KJE95651; CAOG_006078.
DR GeneID; 14896891; -.
DR eggNOG; KOG2059; Eukaryota.
DR eggNOG; KOG4236; Eukaryota.
DR InParanoid; A0A0D2UKS4; -.
DR OrthoDB; 22721at2759; -.
DR PhylomeDB; A0A0D2UKS4; -.
DR Proteomes; UP000008743; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20826; C1_TNS2-like; 1.
DR CDD; cd00030; C2; 1.
DR CDD; cd05128; RasGAP_GAP1_like; 1.
DR Gene3D; 3.30.60.20; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF60; GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00130; C1_1; 2.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00616; RasGAP; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 2.
DR SMART; SM00239; C2; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 2.
DR PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008743};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..118
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 129..257
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 282..332
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 382..430
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 477..671
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 741..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 105735 MW; 0F84F406CA3E9C8C CRC64;
MASPLMRSAT QREHGAHIRK DHNLWVSVVE AKNLDIDDRC STYCLLKINN QERGRTKTVK
KNQAPLYNDD YTFNLSDTFK ELSVVVWNEQ KRGDKPLGQL HIPKDFLASD HLQHEEWFTI
EPALDEGSVK GSATLEVIYT RGAGPDDADK VTVVVVSAKD LISKDANGLS DPFAVLHLLP
DPEFETTQKT KLKKETLAPV FNEMFNYSIP KKGGMPKYRC LFFTLWDWDR FGENDFLGQV
LIDFEDLFRV NPNDNPIKYN ESHTLLPKTV IDPMAAAPAA RDHKFSIHSY KSPTWCYVCS
GFLYGLARQG VKCKDCGFNC HEKCVMQVPS NCRGDKMKRI KKMSKGLLSH KITSQQAYVL
EVQDDLLKAL ALGPQAPGRA KPHLFEPKFF KQPSNCGHCY SSMWMVEGAQ CTHCGLNCHE
KCKINIPALC GTVGQVRIKY KYTDDPVLSL STYLPLYEVL PEQDYYIIML LQAASNQKED
VARCLVRIFE GQGNALTFLN TMARKEVTST ADPNTIFRGN SLATKAFDAY LKLHGMPYLH
SVLKPIISSI VFDNVNCEVD ETRLDKGEDL SKNWKNLKAI VSRTFDAVLG SATSCPFEFR
VLFGHLRELV QKQFPTDAVI PYTAISGFIF LRFFCPAILG PQLFEMMDDL PSPRIGRTLT
LVAKTLQNLA NLVEFGGKEP FMVKMNELIV KRRDDMKAFL DKLSTPVTVA SAPNAKIDLE
VELSRLYRFF LQCRDKMHVA HKERGQNAPG KKEVERIPSW DPRYKESKQP ENQVTFVRFL
DVLEDLTRKH KVAVSQDSEA SSPAPLTPRS RLSGLLGQNQ SAILQEVTES LLRTARQALS
SLANSDGVEE ALDSVKPLLV SAHQMVLIAE FALPDITAEG TNQAKVALEL FSAHIPKIAG
VLKNVAVGEG ADFNVQNVVA GMTPVIKELG VLASNLNSAV AHLPV
//
