ID   A0A0D2WIH2_CAPO3        Unreviewed;       795 AA.
AC   A0A0D2WIH2;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=HELP domain-containing protein {ECO:0000259|Pfam:PF03451};
GN   ORFNames=CAOG_000417 {ECO:0000313|EMBL:KJE88838.1};
OS   Capsaspora owczarzaki (strain ATCC 30864).
OC   Eukaryota; Filasterea; Capsaspora.
OX   NCBI_TaxID=595528 {ECO:0000313|EMBL:KJE88838.1, ECO:0000313|Proteomes:UP000008743};
RN   [1] {ECO:0000313|Proteomes:UP000008743}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 30864 {ECO:0000313|Proteomes:UP000008743};
RA   Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA   Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA   Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA   Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Capsaspora owczarzaki ATCC 30864.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC       {ECO:0000256|ARBA:ARBA00006489}.
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DR   EMBL; KE346360; KJE88838.1; -; Genomic_DNA.
DR   RefSeq; XP_004365288.1; XM_004365231.2.
DR   AlphaFoldDB; A0A0D2WIH2; -.
DR   STRING; 595528.A0A0D2WIH2; -.
DR   EnsemblProtists; KJE88838; KJE88838; CAOG_000417.
DR   GeneID; 14902121; -.
DR   eggNOG; KOG2106; Eukaryota.
DR   InParanoid; A0A0D2WIH2; -.
DR   OMA; ICCADFH; -.
DR   OrthoDB; 2959353at2759; -.
DR   PhylomeDB; A0A0D2WIH2; -.
DR   Proteomes; UP000008743; Unassembled WGS sequence.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13720:SF50; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2; 1.
DR   PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 10.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008743};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          154..222
FT                   /note="HELP"
FT                   /evidence="ECO:0000259|Pfam:PF03451"
FT   REPEAT          515..556
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          643..684
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          710..743
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          760..795
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          45..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          7..41
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        68..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   795 AA;  82297 MW;  17BAAF8DDFB021CF CRC64;
     MATVEEVAEL RAEVARLAQT VESQQAAIAD LTQTVAKLTA AGATTAQRST LGGASPAAAA
     ARRTPATAAA AATTTGTPSR SLSASAATAS PARSAASSTT TAPAAGARRT TATATAAPGS
     PAARGRVPLT NGSAAKAPAA SSAAAVPGPE PHHYFIQGRR IVVHPPTGYV KPTEPASAPE
     VGLTLSHVHG FRGRDTFNNL FLVDEGRTAI WNTAAVVVLQ DVETGRQRHL LGHTDDITCL
     AVDATRKFAV TGQVCSKGKG EKAYLILWDL TTGTAVGHLG GKNIGGHDQS VACAAFSADG
     SHILSIGNDT EHTAIVWNAA TRAQVYTAPG GQDKVVAVGA VPNTSTNWIS VGTHHVSFWG
     AVDDKPFARK KGIFGKHGDQ QTIVSVAYNE SGSRAVTGTA KTGEILLWNV ATASVLASAS
     SGNVGEAGNS ILGLRAVPGH PGSFISTDKL KNAQVWQLAE NDTLTAGASS PIGIEARAID
     VLGSRLVVGG VDHTAKLFQL AADGLTVQGA GVVLTSAHSA EVWALAHHPS KTQFATAADD
     KKLTIFDAVT HAQLQTTALP GAARSVSYNS DGTFIAVGLN DGRFVVLQGD TLEVVGGRKD
     RKEEIADIRF SSTVPSILAV ASHDNFIDVY HVAAGAIERK AICKGHSSFI THIDWSADGR
     FLRSTSGDYE LLFWEALTGK QVTASVDVRD LTWASQTCVL GWDVAGIWPP DSDGTDVNAV
     SASPDNTLLA SGSDDGFVRL FRIPVLEPGR NIMAPAKEYG ARHSAHVTNV RFSRDGKSLV
     STGGNDCTIM LWTVA
//