ID A0A0D2WJA6_CAPO3 Unreviewed; 884 AA.
AC A0A0D2WJA6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Inositol 5-phosphatase 4, variant 2 {ECO:0000313|EMBL:KJE90079.1};
DE SubName: Full=Inositol 5-phosphatase 4, variant 3 {ECO:0000313|EMBL:KJE90080.1};
GN ORFNames=CAOG_001452 {ECO:0000313|EMBL:KJE90080.1};
OS Capsaspora owczarzaki (strain ATCC 30864).
OC Eukaryota; Filasterea; Capsaspora.
OX NCBI_TaxID=595528 {ECO:0000313|EMBL:KJE90080.1, ECO:0000313|Proteomes:UP000008743};
RN [1] {ECO:0000313|EMBL:KJE90080.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 30864 {ECO:0000313|EMBL:KJE90080.1};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capsaspora owczarzaki ATCC 30864.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000008743}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 30864 {ECO:0000313|Proteomes:UP000008743};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capsaspora owczarzaki ATCC 30864.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase
CC type II family. {ECO:0000256|ARBA:ARBA00005910}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE346361; KJE90079.1; -; Genomic_DNA.
DR EMBL; KE346361; KJE90080.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2WJA6; -.
DR EnsemblProtists; KJE90079; KJE90079; CAOG_001452.
DR EnsemblProtists; KJE90080; KJE90080; CAOG_001452.
DR Proteomes; UP000008743; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052745; F:inositol phosphate phosphatase activity; IEA:InterPro.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09093; INPP5c_INPP5B; 1.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR037793; OCRL1/INPP5B_INPP5c.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF299; PHOSPHOINOSITIDE 5-PHOSPHATASE; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF00620; RhoGAP; 2.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000008743}.
FT DOMAIN 664..882
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 631..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 884 AA; 100459 MW; 9BC8F9253F86FF2E CRC64;
MSLLKKNQLD INLALPIFPE VEVTLLDSNP NAKKAKTGLL KLTWAGESDT EEVVFEVALG
EYVQQFVQEF KAAKAVAVNE GQVTAGATHA WISNYINKQP ISIVATPEMT PVENYFRQLN
NVQNIDAPEN LMDTYMARSA FEYNPQTLKS VKEEWIAKQL EIKKSEFTEP RTLTLLCGSW
NVNGRTPKEN LAPWLIPNEH PELPDVYAVG FQELDLSAEA FVFNESNREA MWCAMIEDCI
NLDKVYTKVK SKQLVGMLLC VYVKTVHIPH IRNVQAVVTG TGIMGMMGNK GGVAIRFRLF
DTDLCFVNSH LASDSGRCDR RNQDYQEVVK RTLFTMPNGP PFTIFDHDLV FWVGDLNYRI
PLPDSEVKSL VKARDYQKLL KYDELTVERN AKHVFVGFEE GPIDFYPTYK FDVGTDTFDS
SEKQRTPAWC DRVLWKGAGV KQRTYTGHMV FRTSDHKPVS SLVDFAVQVV QPKRFAEVRQ
QIVREMDKME NECRPDAVIS TNLAKFPDVK FMTRYTQSIV IENSGQVILQ FRFIPKLDEK
KFCKPWLRIN PPVGMIVPGE KATVELMLMV DATTAASLNT GEERLEDILI LHLENGKDYF
VSITGNFLRT CFCTPLVTLV NTLRPVRDLT QPAAASSSSD RRTKSQPPQP NLIDFGESAS
TPAAPTSKPE EPKKLHIPKE LWRMVDFLFT YGLDEDNLFA TSGNEQSMEL IRECLDTGLP
FETMPDAVHS ISECLIRFLE ALPDPVIPFV HYQRCLDSNS NYTLCKQVSC CERGFLFFFF
FCSRGCYYCV GLTQRFVCWW LLPQVLTQLP SEHYNLFVYL MAFLREVLSH AVTNGLSAEK
LALLFSAVLL RPGPDKTRDA ASTKKASNFI YHFLLNDEEP QFAS
//
