ID A0A0D2WLQ6_CAPO3 Unreviewed; 1516 AA.
AC A0A0D2WLQ6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 13-SEP-2023, entry version 43.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAOG_002128 {ECO:0000313|EMBL:KJE90893.1};
OS Capsaspora owczarzaki (strain ATCC 30864).
OC Eukaryota; Filasterea; Capsaspora.
OX NCBI_TaxID=595528 {ECO:0000313|EMBL:KJE90893.1, ECO:0000313|Proteomes:UP000008743};
RN [1] {ECO:0000313|Proteomes:UP000008743}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 30864 {ECO:0000313|Proteomes:UP000008743};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capsaspora owczarzaki ATCC 30864.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE346362; KJE90893.1; -; Genomic_DNA.
DR RefSeq; XP_004348878.1; XM_004348828.2.
DR STRING; 595528.A0A0D2WLQ6; -.
DR EnsemblProtists; KJE90893; KJE90893; CAOG_002128.
DR GeneID; 14900186; -.
DR eggNOG; KOG3629; Eukaryota.
DR InParanoid; A0A0D2WLQ6; -.
DR OMA; QHININQ; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000008743; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF312; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000008743}.
FT DOMAIN 357..478
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 864..1097
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 36..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1466..1516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..79
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..210
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 797..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1475..1516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1516 AA; 160226 MW; E8863B9D8D202532 CRC64;
MASASDGMDA GAANGALKRN EKKRSFKLLS RLNSLTSFGS ALPPPTPTGT SATSSSPVMS
STNSGSDSAS GSGSATPLFA SAATAIAADE TRPPRLDEDD ETEREHESTT TTTTTTTSTA
ASADSPVPAA SATSSSAPGS GSSSPAGAAV TATNSGSSSS SSSTSHSINS HSSSNAAIRG
SSTLVRRSSA LSPPPLNLAQ PTPPPLQPSS QGTPIYSTPL QATSSHASSS RDRFSFSSSG
SSSSLAMLAA TEEVLPDVVF TLSRKKASAV AQLHLQHQQQ AQQVQQQLLQ QQQSQQPTSP
QPLPSPPPRT SIDSVTSNSS SSSDSSSAGT SSTAPAPLPA PVQPVSSASL RSSYTAVDRK
VKAASFGRLI ERLAPYDATA VDNFFMSVFF TTYRAFARPP EVLTALCDRF SQPINADVLV
STAAYAERFV AQAAAAAADA SSTSASSAAP PADAEADTSD SLFSFMTAQF RHLQATRNVD
PTPPLSAATS SEDMLITHRD THSALPILLE ASSSLQQSEP QSEPQPQQQQ QQQQQQQQQQ
QQQQQQQPSH PPLCRVSSLP MQIPNSSITP FATVRSGGHR HHRQSLENQS PTLGSFSASS
LPVNFAHLHG YSSAELGRDR RDSVASNVST TSSSSDANAL ASSVEALSGG HSASAPEHIP
DDFVSMVRLR VTFAFSVWIN QHWYDFRDAL GQQCLTQLRE FLETTVCANP GTTNLGQLLV
RTIDFKVSNP TSGMWQLPTP QTSAASSASP SIASLSAHAP SAALSGLSSS HLHGHSHKRR
VSESRLSGSF GFMSRLSSSG GSGTHSPNPA AVPSPAVSAL PSPMMLASTS GSFNGTANPI
SPTGDSEQTV AAFPSLSLRH LDINAANFAR QLTLVEAALY RDVMPSECLG SGWTKKDKAV
KSPSIVASIQ HFNRVSTLVM TEVLRPEDRV SRVEQMVFFI EVAKECRVLC NFASLKAIVS
ALQSTPVHRL KKTWSLMKKD HVATFEDLCD LVSERSNYQR LRDTLRTTNP PCIPYLGCFL
TDLTMVDSAN SDLYGSTQLI NFEKRRKEFE IIEVVCWFQR NCQYSLIPVP HFQSWLSNAL
VLNEDECYKL SLIREAREDS SSAAVSAALL AAALSGGAST PLPGKSTSAL ATLSTPSPAP
EPALGTSVDS SSSSTGSPLR RSFNSAPSLS AILEQQQQQQ QQQQQTNSAV DKPPTAVQPV
NATEEASANT GEASTTSPPS ASLGPAQTEA PVSKLALLLQ DSMSSELVTS LEERNSAVDR
LRKFIASRPT SLRNFYDTNV KAFGRQDSSF MTPVDPGSPR AKKSSKPLAL SSRAGSSELL
AQVETAASVP TDPDAVPIRV RAGPSITQRL SKKKSDKIKT IVVNPNATEA SVIIQALERL
KIHEAPENCR LVCVTSRGLI RFSDESVFLP PQEDGMEPPL FVLEATGADL LSRATSPARA
RFLRAQSAGP NAFAPALLQR QSLSMNEDAS ELPDHLSSLL SSPLSGNSEG DVSSSPYTSQ
EDMLPPGTSS VPETCL
//
