ID A0A0D2WUL7_CAPO3 Unreviewed; 1772 AA.
AC A0A0D2WUL7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=CAOG_009003 {ECO:0000313|EMBL:KJE96405.1};
OS Capsaspora owczarzaki (strain ATCC 30864).
OC Eukaryota; Filasterea; Capsaspora.
OX NCBI_TaxID=595528 {ECO:0000313|EMBL:KJE96405.1, ECO:0000313|Proteomes:UP000008743};
RN [1] {ECO:0000313|Proteomes:UP000008743}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 30864 {ECO:0000313|Proteomes:UP000008743};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capsaspora owczarzaki ATCC 30864.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE346371; KJE96405.1; -; Genomic_DNA.
DR STRING; 595528.A0A0D2WUL7; -.
DR EnsemblProtists; KJE96405; KJE96405; CAOG_009003.
DR eggNOG; KOG0192; Eukaryota.
DR InParanoid; A0A0D2WUL7; -.
DR Proteomes; UP000008743; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Kinase {ECO:0000313|EMBL:KJE96405.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008743};
KW Serine/threonine-protein kinase {ECO:0000313|EMBL:KJE96405.1};
KW Transferase {ECO:0000313|EMBL:KJE96405.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 727..747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 899..918
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 815..1185
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1653..1772
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1224..1266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1402..1426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1402..1422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1772 AA; 194385 MW; BE8C7F758C565EF8 CRC64;
MSHLDAHADG LARHSAQNER DNVRKTRSIG MAEIATLTLA EPTHQKFRRR HHRQASSSSL
RPVLSAISLL LVALLLLSGN VRAPSTLPVG GGGGFLQSAP FGGVDALPSN NRHSDDADAD
ALEPPFHLED EPLVVQQVRS GGGMEGALGS AHELNEQDGE ARKNDAFQRS QGQAAAMHRR
PRELAEDDNL TEQADGDSAA SISPNNSKVF MEQASASPTA PTGTTIRLVW YDHRGCKALQ
TVTSLYPEQN VHVEVACLPA EEYNQIPLTP DGAKAYSMDL VTFSPYLLGE AVSTGMLLQF
PDGVLDTTST SFFAENLALH GEFPPNSNRF YGVPLEGDVP LLAYRNDILQ LAAITNPELF
GSAGLRAPQS LSDLIQFSRF FYNSSFVPYG FAASWCGTET YLTKACRGQT TLVATNFIWG
ADGLLFNETT FRAFVSEPYN SNANIGLAVV NALYQTSAKD MTGGESEAIK LFCTGQAAFL
MVWTSVVNEQ LGDLCRGFFD TPPPYPTLSS NNLIIWDPKD SVLKRRQVDA IDDNDDAFDD
NADEMDNSQA HFRKSKLPVH RRAPGDPFTV SYQVLPLTQR RAGVGSHQAG GWSLGIASTT
PNLEAAARVL DWIFEIDQQV QLESLGMLPT QRSLVLDRYF LEQLAPSFGL AYALSFPSAT
SILSTEVTRQ VTRLSDLYFS QAIFGTLDIR SAMTVYRTRA DAILVDAYPC GPECPPVPSS
HLSAGEYVAI IVPAAVVMII LLVVCLYRRA EKRINAMEKK QYQIDYNELE NIEDPSCELH
TTAFYSANQQ PVFISRVDPV KVAPLLASAG IITRARMSKS AASGGLDVEA AGGSPDADGG
PDGAAVAPRR TSWQQSVRDT TNNCISILPG LISAHRTWRI SRESSQALKR LRSLKHPNVV
EFLGITVAPQ CFAVYEFMVK GSLLTVIERD GLPHDMDFKC SMAADIARGM LYLHSHGVLH
KHLRLTKILL DNRFVCKISG ASEQHNLLQQ REYNHHPHHH SAIESSAMAA LAAGALGTAI
PPDQLANYQA TTTPGRRASS MSTSSNSSAL SALRVRALLG QGGDGLGNDR AEHPVDQRIA
DGRQELLTET STSAKPWYQQ RTTSWPALFA NKAKGAFRRP SASTQSAESQ TPTSSRKGSA
IDAAAAPQQQ QQQQQQQQQS QMRQANNTAR VALAPALSTI EEPSVDDAVV LASTGNTNNQ
QSAAGRTATQ NSAVVFVPAA GEEMSQLPRT TDNSAAQQPR RHWLHHRANG TASDDDEDED
AYDGVERNEL SSIDESMESV TDEDRAAEYS IAQDQLRSLA QVRDIMNARG RRKSAIDITL
PPILRSASSK RSSESTRSSQ QSQHAAVLVP SNVIVEMPHP LDAQAKESTS SHAHSRRESY
QSHLAPLVIP HDDNHSEARA NSKLVEPTDE QKQDEQTDHL EGQDQPLEPV VSGISLASAS
PGSTSPTRAP LASRRVTITH AINTNVNPEH LLWMAPEVLQ EKILAHSRVD EKLYMTEKAD
VYSFGLIIYC LFMDITHPFD LELQPEAIFD AIVKRQVRPE LDDTLELTDV EMQVVQLIQQ
CWQPHALFRP NFRTLLESFE KLYPAENKGF EKMAFMLEKY STHLEEIVDS RSTQLKEEKL
RAETLLTNML PVTIANRLRS GAGFIADEFP TCTVFFSDIQ GFTAMAHQAS PNEIVRMLNK
LFTRMDRLAG KYELEKIKTI GDAYMAACGV PTYIENHAEK VVQFAMHVLR NNTCDIHNQP
IRMRIGIHTG PLIAGVVGTR KFTYDLWGDT VG
//
