ID A0A0D2X1I6_CAPO3 Unreviewed; 500 AA.
AC A0A0D2X1I6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Steroid 5-alpha reductase family enzyme {ECO:0000313|EMBL:KJE90874.1};
GN ORFNames=CAOG_002111 {ECO:0000313|EMBL:KJE90874.1};
OS Capsaspora owczarzaki (strain ATCC 30864).
OC Eukaryota; Filasterea; Capsaspora.
OX NCBI_TaxID=595528 {ECO:0000313|EMBL:KJE90874.1, ECO:0000313|Proteomes:UP000008743};
RN [1] {ECO:0000313|Proteomes:UP000008743}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 30864 {ECO:0000313|Proteomes:UP000008743};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capsaspora owczarzaki ATCC 30864.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KE346362; KJE90874.1; -; Genomic_DNA.
DR RefSeq; XP_004348861.2; XM_004348811.2.
DR AlphaFoldDB; A0A0D2X1I6; -.
DR EnsemblProtists; KJE90874; KJE90874; CAOG_002111.
DR GeneID; 14900169; -.
DR eggNOG; KOG4650; Eukaryota.
DR InParanoid; A0A0D2X1I6; -.
DR OrthoDB; 38588at2759; -.
DR PhylomeDB; A0A0D2X1I6; -.
DR Proteomes; UP000008743; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 1.20.120.1630; -; 1.
DR InterPro; IPR001104; 3-oxo-5_a-steroid_4-DH_C.
DR InterPro; IPR010721; UstE-like.
DR PANTHER; PTHR32251; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; 1.
DR PANTHER; PTHR32251:SF15; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295); 1.
DR Pfam; PF06966; DUF1295; 1.
DR PROSITE; PS50244; S5A_REDUCTASE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008743};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 376..458
FT /note="Steroid 5-alpha reductase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50244"
SQ SEQUENCE 500 AA; 52921 MW; 75D423E471B80F44 CRC64;
MDALRGLASQ IAVLVVPASP PPSTPGDSGS LPPLDALLEQ LLSTRLGVAI AAAAFVGACS
GIARVMLANS LPAVVGGVQV PATTPPPPSS TPTSVSPAAA AAASGPAAVG DAAAPISSSG
GLITAVAFSP FHLAAWATEQ AAKAVARVAA APNGQVGATA PAASADAVAA AGTGSGTSQL
FSVIRAAIRG LLVPVHVVNS VRRAVHNAAF HGAKLLAAVL RQSLPSFSQV LENSPRLGGL
LSLLCASSLL WLVSVRINDV SIVDPFWSLG FLILTAVFRN HRATATGFAG RKDLILLLVS
LWAVRLSAYL FYRNYGQGED FRYQAFRRRH GPKYWWVSLF QTFWLQSVLC FLVGFPLLTA
QRGSAPMYFT DKDLVGATMW VVGFLFEAIG DLQLTLFKRN PANEGKLLTT GLWRFTRHPN
YFGNALMFWG YYVIACNARF GWTTIPAPLL MTYLLTSLSG VPMLERSLIR KKPEFVAYAA
RTSAFIPWFP ANIDSASIVL
//