ID   A0A0D3AJ70_BRAOL        Unreviewed;       429 AA.
AC   A0A0D3AJ70;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   08-NOV-2023, entry version 32.
DE   RecName: Full=Cystathionine gamma-synthase {ECO:0008006|Google:ProtNLM};
OS   Brassica oleracea var. oleracea.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX   NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo2g012530.1, ECO:0000313|Proteomes:UP000032141};
RN   [1] {ECO:0000313|EnsemblPlants:Bo2g012530.1, ECO:0000313|Proteomes:UP000032141}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX   PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA   Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA   Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA   Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA   Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA   Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA   Chalhoub B., Sharpe A.G.;
RT   "Transcriptome and methylome profiling reveals relics of genome dominance
RT   in the mesopolyploid Brassica oleracea.";
RL   Genome Biol. 15:R77-R77(2014).
RN   [2] {ECO:0000313|EnsemblPlants:Bo2g012530.1}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (MAR-2015) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|RuleBase:RU362118}.
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DR   AlphaFoldDB; A0A0D3AJ70; -.
DR   STRING; 109376.A0A0D3AJ70; -.
DR   EnsemblPlants; Bo2g012530.1; Bo2g012530.1; Bo2g012530.
DR   Gramene; Bo2g012530.1; Bo2g012530.1; Bo2g012530.
DR   eggNOG; KOG0053; Eukaryota.
DR   HOGENOM; CLU_018986_1_2_1; -.
DR   OMA; CVCGSME; -.
DR   Proteomes; UP000032141; Chromosome C2.
DR   GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:InterPro.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR044639; CGS1/2.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR43379; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR   PANTHER; PTHR43379:SF1; CYSTATHIONINE GAMMA-SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 3.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032141}.
FT   MOD_RES         227
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   429 AA;  47613 MW;  0EC6AA5680C4B365 CRC64;
     MALYRSISLR SVSSDPQPSC FTGYGRVSSF ILRFPPNIAR QLSTKARGNC NFSVAQTVVA
     KWSNSTRSGL TSVPAVTSVD EEVLVAAESV KEMEKRVVHH EYGRYGNPTT LVLEKKISSL
     NFFWNMEPVH LKVLNQLWLW HLGCVQVTVI DPVDTTGLEA AVNNHEVSMF FTESPTNPFL
     RCVDIELVSE ICHKRGTLVC IDGTLATPLN QKALALGADL VVHSATKYIG GHNDVLGGCV
     CGSMELVSAI RNLHHVLGGT LNPNAAYLLI RGIKTMHLRL KQQNSTALRM AQVLEAHPKV
     LYFPPKKPFF LYIYIFLVSR VYYPGLISHP EHHIAKRQMN GFGGVVSFEI AGDLETTIKF
     VDSLNIPYIA PSFGGCESIV DQPAIMSYWD LPQEERLKYG IKDNLVRFSF GIEDFDDVKA
     DVLQALGTI
//