ID   A0A0D3AZ99_BRAOL        Unreviewed;      1073 AA.
AC   A0A0D3AZ99;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Tower domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Brassica oleracea var. oleracea.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX   NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo3g001340.1, ECO:0000313|Proteomes:UP000032141};
RN   [1] {ECO:0000313|EnsemblPlants:Bo3g001340.1, ECO:0000313|Proteomes:UP000032141}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX   PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA   Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA   Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA   Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA   Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA   Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA   Chalhoub B., Sharpe A.G.;
RT   "Transcriptome and methylome profiling reveals relics of genome dominance
RT   in the mesopolyploid Brassica oleracea.";
RL   Genome Biol. 15:R77-R77(2014).
RN   [2] {ECO:0000313|EnsemblPlants:Bo3g001340.1}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (MAR-2015) to UniProtKB.
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DR   AlphaFoldDB; A0A0D3AZ99; -.
DR   STRING; 109376.A0A0D3AZ99; -.
DR   EnsemblPlants; Bo3g001340.1; Bo3g001340.1; Bo3g001340.
DR   Gramene; Bo3g001340.1; Bo3g001340.1; Bo3g001340.
DR   eggNOG; KOG4751; Eukaryota.
DR   HOGENOM; CLU_004336_0_0_1; -.
DR   OMA; MMELYNQ; -.
DR   Proteomes; UP000032141; Chromosome C3.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   CDD; cd04493; BRCA2DBD_OB1; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   PANTHER; PTHR11289:SF4; PROTEIN BREAST CANCER SUSCEPTIBILITY 2 HOMOLOG B; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   Pfam; PF00634; BRCA2; 2.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   PROSITE; PS50138; BRCA2_REPEAT; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032141};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          491..565
FT                   /note="Breast cancer type 2 susceptibility protein helical"
FT                   /evidence="ECO:0000259|Pfam:PF09169"
FT   DOMAIN          569..693
FT                   /note="BRCA2 OB1"
FT                   /evidence="ECO:0000259|Pfam:PF09103"
SQ   SEQUENCE   1073 AA;  117946 MW;  640AF8D86FEE1D57 CRC64;
     MSTWSLLPDS SGNCFRWEVA GRILQSDSED SAIESTAPLP SMNDLLLQGW SKLKQGDGAL
     FRTGMGNSVA LKAKSVLEDE HHHHPDGGSN LQSDSAATLP MFRTASGRSV PLKDSSIAKA
     ISILGPPHSD NVPLRESGFG DPNSFFQTPS NKMVIVDDFT GFNHVKRSNQ KRGCSELKTH
     ATGVLHHSET PGQYEGHVFQ KISESLYPSA VVPPTMFQTA GGKTLSVSVQ ALKRARNLLG
     DPDSVTLFDD VPAVDQFSTP QKVQRLGDLP INNRNANTGY NAFEGKTSNK HTATSFVSPL
     RSSSKQFRSV KLEDLASGGN LIKKFDAAVD DTDRALNTTK LATHGVSNNR PMAVNNAKAN
     GFIPIAKQSG QPLVDITNRS ANNKQDSTQK KRLGKTIFVS PFKKPRNSSF KTPLKKNAQH
     ALSGLSIVSS DTLNSKKVLS TRYPERSPRV YIKDYFRMHP TVTTKMNYVP DHVRRIKSSN
     ADKYVFRDES SSNMVGAETF FQMLAESGAS LRQASRKWVI NHYRWIVWKL ACYETCYPVI
     CRGNFLTITN VFEELKYRYE REVNHGHCSA IKRILSGDAP ASSMMVLYIS AINPKTDNDS
     QKALGSGSGS NVKVELSDGW YSMNAALDVN LTKQLNAGKL FVGQKLRILG AGLSGWATPT
     SPLEAVISNT ICLLLNINGT YRAHWADRLG FCKEVGAPLA FNCIKGNGGP VPKTLAGITR
     IYPILYKERR SALIEGLMCE YERGGNGVHS QNDTDSEEGA KVFKLLETAS EPELLMAEMS
     LEQLTSFTTY KSKFEAAKQI QMEKSVAQAL EEAGLSERDV TPFMRIRLVG LTSLSYEGVH
     NPKEGIVTIW NPTERQRTEL TEGKIYIMKG LVPTVSDSET LYLHARGSSS RWEPLSPKAS
     SSFQPFFNPR KPISLSNFGG IPLSSEFDIA AYVVYVGNVY TDVEQKKQWV FVTDGSTQRS
     RSGEISNSLL AISFSTPSMD DLPTPHISHS LVGSVVGFCN LIKRAKDAKN NMWVGEATEN
     SVYSINAEAA YSSHLKTSSS HIQTWAKLSS FNSVIHKLRQ IVLFVIGAST CSR
//