ID A0A0D3B4K1_BRAOL Unreviewed; 999 AA.
AC A0A0D3B4K1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 1 homolog {ECO:0000256|PIRNR:PIRNR015947};
GN Name=106335341 {ECO:0000313|EnsemblPlants:Bo3g026790.1};
OS Brassica oleracea var. oleracea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo3g026790.1, ECO:0000313|Proteomes:UP000032141};
RN [1] {ECO:0000313|EnsemblPlants:Bo3g026790.1, ECO:0000313|Proteomes:UP000032141}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA Chalhoub B., Sharpe A.G.;
RT "Transcriptome and methylome profiling reveals relics of genome dominance
RT in the mesopolyploid Brassica oleracea.";
RL Genome Biol. 15:R77-R77(2014).
RN [2] {ECO:0000313|EnsemblPlants:Bo3g026790.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SUBUNIT: Component of the 19S regulatory particle (RP/PA700) base
CC subcomplex of the 26S proteasome. The 26S proteasome is composed of a
CC core protease (CP), known as the 20S proteasome, capped at one or both
CC ends by the 19S regulatory particle (RP/PA700).
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR RefSeq; XP_013629293.1; XM_013773839.1.
DR AlphaFoldDB; A0A0D3B4K1; -.
DR STRING; 109376.A0A0D3B4K1; -.
DR EnsemblPlants; Bo3g026790.1; Bo3g026790.1; Bo3g026790.
DR GeneID; 106335341; -.
DR Gramene; Bo3g026790.1; Bo3g026790.1; Bo3g026790.
DR KEGG; boe:106335341; -.
DR eggNOG; KOG2062; Eukaryota.
DR HOGENOM; CLU_002323_0_0_1; -.
DR OMA; IMFGRQE; -.
DR OrthoDB; 151732at2759; -.
DR Proteomes; UP000032141; Chromosome C3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 1.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000032141};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 780..803
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..353
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 796..954
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 853..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 999 AA; 108406 MW; 245F2FB47308C89E CRC64;
MAAAMVSSAG GLLAMLNEPQ PSLKHHALSH LNNLVDRFWP EISTSVPIIE SLYEDEEFDL
HQRQLAALLV SKVFYYLGEL NDSLSYALGA GPSFDVSEDT DYVHTLLAKA IDEYASLRSK
AFESNEMVDI DSRLEAIVER MLEKCITDKK YQQAMGIAIE CRRLDKLEEA ITKSDNVEGT
LSYCINVSHS FVNRREYRHE VLTLLVKVFQ QLPSPDYLSI CQCLMFLDEP QGVASILEKL
LRSESKDDAL LALQIAFDLV ENEHQAFLLS VRDRLPAPKT RPVEAVQAVE TTTAPTENPS
GDVPMADGTP APTIVHETDP VDATYAERLA KIKGILSGET SIQLTLQFLY SHNKSDLLIL
KTIKQSVEMR NSVCHSATIY ANAIMHAGTT VDTFLRENLD WLSRATNWAK FSATAGLGVI
HRGHLQQGRS LMAPYLPQGG AGGGGSPYSE GGALYALGLI HANHGEGIKE FLRDSLRSTN
VEVIQHGACL GLGLSAIGTA DEEIYDDVKS VLYTDSAVAG EAAGISMGLL LVGTATEKAS
EMLAYAHETQ HEKIIRGLAL GIALTVYGRE EGADTLIEQM TRDQDPIIRY GGMYALALAY
SGTANNKAIR QLLHFAVSDV SDDVRRTAVL ALGFVLYSDP EQTPRIVSLL SESYNPHVRY
GAALAVGISC AGTGLSEAIS LLEPLTSDVV DFVRQGALIA MAMVMVQISE ASDSRVGTFR
RQLEKIILDK HEDTMSKMGA ILASGILDAG GRNVTIRLLS KTKHDKVTAV IGLAVFSQFW
YWYPLIYFIS LAFSPTAFIG LNYDLKVPKF EFMSHAKPSL FEYPKPTTVA TANTAAKLPT
AVLSTSVKAK ARAKKEAEQK ANAEKTSGAE KSVNESGSGK EKEGDAMQVD SSATAEKKAA
EPEPAFEILV NPARVVPAQE KYIKLLEDSR YVPVKLSPSG FVLLKDLREH EPEVLSLTDA
PTSTASPATG AAAATQGTTA SAMAVDDEPQ PPQAFEYAS
//
