ID A0A0D3CL18_BRAOL Unreviewed; 1118 AA.
AC A0A0D3CL18;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=106295443 {ECO:0000313|EnsemblPlants:Bo5g135050.1};
OS Brassica oleracea var. oleracea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo5g135050.1, ECO:0000313|Proteomes:UP000032141};
RN [1] {ECO:0000313|EnsemblPlants:Bo5g135050.1, ECO:0000313|Proteomes:UP000032141}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA Chalhoub B., Sharpe A.G.;
RT "Transcriptome and methylome profiling reveals relics of genome dominance
RT in the mesopolyploid Brassica oleracea.";
RL Genome Biol. 15:R77-R77(2014).
RN [2] {ECO:0000313|EnsemblPlants:Bo5g135050.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR RefSeq; XP_013586795.1; XM_013731341.1.
DR AlphaFoldDB; A0A0D3CL18; -.
DR STRING; 109376.A0A0D3CL18; -.
DR EnsemblPlants; Bo5g135050.1; Bo5g135050.1; Bo5g135050.
DR GeneID; 106295443; -.
DR Gramene; Bo5g135050.1; Bo5g135050.1; Bo5g135050.
DR KEGG; boe:106295443; -.
DR eggNOG; KOG1863; Eukaryota.
DR HOGENOM; CLU_003532_0_1_1; -.
DR OMA; NVECLSM; -.
DR OrthoDB; 51419at2759; -.
DR Proteomes; UP000032141; Chromosome C5.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00121; MATH; 1.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006:SF942; UBIQUITIN C-TERMINAL HYDROLASE 12; 1.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000032141};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 55..180
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 200..524
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
SQ SEQUENCE 1118 AA; 130571 MW; 529607EF05731373 CRC64;
MVTPTPLDQQ EDEEMLVPHS DVVEGPQPME VAQPEAAAAA AAAAVENPPV EEPPTMKYTW
TIPGFTRLNT RKHYSDVFVV GGYKWRVLIF PKGNNVDNLS MYLDVADAAN LPYGWSRFSQ
FGLAIVNQIN SSYSIRKESQ HQFNSRESDW GFTSFMPLSE LYDPTRGYLV NDTVVIEAEV
AVRKVLDYWS YDSKKETGFV GLKNQGATCY MNSLLQTLYH IPYFRKAVYH MPTTENDAPT
ASIPLALQSL FYKLQYNDTS VATKELTKSF GWDTYDSFMQ HDVQELNRVL CEKLEDKMKG
TVVEGTIQKL FEGHHMNYIE CINVDYKSTR KESFYDLQLD VKGCKDVYES FDKYVEVERL
EGDNKYHAEG HDLQDAKKGV LFIEFPPVLQ LQLKRFEYDF MRDTMVKIND RYEFPLELDL
DRDNRKYLSP DADKSVRNLY TLHSVLVHSG GVHGGHYYAF IRPTLSDQWY KFDDERVTKE
DVKRALEEQY GGEEELPQNN PGFNNPPFKF TKYSNAYMLV YIRESDKDKI ICNVDEKDIA
EHLRVRLKKE QEEKEDKKKY KAQAHLFTTI KVARDEDITE QIGKNKYFDL VDHEKVKSFR
IQKQTPFQLF KEEVAKEFGV PVELQRFWIW AKRQNYTYRP NRPLLPHEEL QTVELLREAC
NKTNNAELKL FLEIERGPEE RPIPPPDKSS ADILLFFKLY DPENAILRYV GRLMVKKSSK
PMDIVGQLNQ MAGFAPDEEI ELFEEIKFEP CVMCEHLDKK TSFRLSQIED GDIICFQKPL
SIQENECPYP DVPSFLAYVQ NREVVRFRSL EKPKEDEFTM ELSKLHTYDD VVQRLAEKLG
LDDPSKIRLT SHNCYSQQPK PQPIKYRGVD HLSDMLAHYN QTSDILYYEV LDIPLPELQG
LKTLKVAFHH ATKDEVVIHN IRLPKQSTVG DVINELKTKV ELSHPDAELR LLEVFFHKIY
KIFSSTERIE NINDQYWTLR AEEIPEEEKN IGPSDRLVHV YHFTKEAGQN QAQVQNFGEP
FFLVIHEGET LEEIKSRIQK KLHVPDEDFA KWKFASFSMG RPDYLQDTEV VYDRFQRKDV
YGAWEQYLGL EHVDNAPKRA YAANQNRHAY EKPVRIYN
//
