ID A0A0D3CPV7_BRAOL Unreviewed; 1837 AA.
AC A0A0D3CPV7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=PI3K/PI4K catalytic domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Brassica oleracea var. oleracea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX NCBI_TaxID=109376 {ECO:0000313|EnsemblPlants:Bo6g023600.1, ECO:0000313|Proteomes:UP000032141};
RN [1] {ECO:0000313|EnsemblPlants:Bo6g023600.1, ECO:0000313|Proteomes:UP000032141}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. TO1000 {ECO:0000313|Proteomes:UP000032141};
RX PubMed=24916971; DOI=10.1186/gb-2014-15-6-r77;
RA Parkin I.A., Koh C., Tang H., Robinson S.J., Kagale S., Clarke W.E.,
RA Town C.D., Nixon J., Krishnakumar V., Bidwell S.L., Denoeud F., Belcram H.,
RA Links M.G., Just J., Clarke C., Bender T., Huebert T., Mason A.S.,
RA Pires J.C., Barker G., Moore J., Walley P.G., Manoli S., Batley J.,
RA Edwards D., Nelson M.N., Wang X., Paterson A.H., King G., Bancroft I.,
RA Chalhoub B., Sharpe A.G.;
RT "Transcriptome and methylome profiling reveals relics of genome dominance
RT in the mesopolyploid Brassica oleracea.";
RL Genome Biol. 15:R77-R77(2014).
RN [2] {ECO:0000313|EnsemblPlants:Bo6g023600.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (MAR-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 109376.A0A0D3CPV7; -.
DR EnsemblPlants; Bo6g023600.1; Bo6g023600.1; Bo6g023600.
DR Gramene; Bo6g023600.1; Bo6g023600.1; Bo6g023600.
DR eggNOG; KOG0902; Eukaryota.
DR HOGENOM; CLU_000893_2_1_1; -.
DR OMA; CPHESAI; -.
DR Proteomes; UP000032141; Chromosome C6.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF105; 1-PHOSPHATIDYLINOSITOL 4-KINASE; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 2.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000032141};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1344..1522
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1596..1837
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1837 AA; 204263 MW; B2B8103A95098AFA CRC64;
MEALTDICEI IEENPINFSE NLVWICRQCP HESAIVSRSH LNAVLAVARI ISRNVDTSEN
HGKLAVINFL QAVPNSFRRS FWPCSFTLES ITEFYCAFLG YVSCTSLQFG TIVVEIAVEA
MVSGDDVDTD RGISRAFLVA LSQNGFPSIQ QSDGDMLITV LLHKFSTNSV VHNEEFSHGL
DVASNASCSG GSFSVFRQQV ASSEDESIES LEKQEITFKL MAHVLDKVKV DSKLYDQVNS
IAKRQLQSMS AFLKSRRQDR NDQDSVLKTR VLLVYQAAAK MKIKSLLSLE TDGKAYKKRA
METFTLLFDA AEACLTSVWR KMKACEELFI SLLSGIAEMA VAKGRCLPHG LFVRLKPLVL
AVCAQPDTWV RDQRNIFESV SNICCEIIES GWAKDRALVN TFIVGLASRI RETNDYEDQV
GREKEDPTVR LNVIKLLADI SLAVKKPEVA DMVFPFFIDS LEEGDTSTPG SFRLQLLDAV
SRIAILGFEK SYRETVVLMT RGYLREVLTV ASVESKTSEP KSRTEHIETL AAGFLTIANG
LMNTKRRADY RHRLLSLCSD VSLASESKTG GSGADMLGPL LPAVAEICSA LDPTSNVEPS
LLKLFRNLWF YIALFGLAPP IVKPQPAGGP YMWNTQWSLA VQRISQGTPP LVVSSVKWLE
DEFELNALRS SDSSRGIGNK KVASTQRTAL AIALGGRVEV SALNTISGVK ATYLLAVAIL
EIIRFTSNGG ILNGGSSVSA SRSAFSCAFE YLKSPNLTHA VSQCLTAIVH RAFQAAISWL
EDRISLTGKD DSIRESTMNA HACFLIKNMP QRDELIRDIS VNLLNQIRDK FPQVLWSSSC
LDSLLFSVHD NAPSMVVNDP AWTAAVRSLY QKVVREWIYI SLSYAPCTIQ GLLQDKLCKA
NTLQRTQTTT DVVSLLNEIK IGTGENEIWS GTKTANIPAV MDAAVAASGE NLKASEAFNL
EILGTGFVNA MYKCKHTGQI SGLVRLGNSI GIDKLINSSV RSLQQIVNTS TNGGITDKLQ
FRETCSQATA VLLSNLQAGE PKTDIKGFSR LLRLLCWSPA YILTPDAMET GVFIWTWLVS
AAPQLGSLVL AELVDAWTWT IDSKRGLFAS DVRSYGPAAK LKPQLAPGEP EESPDSDPVD
QIVAHRLWLG FLIDRFEIVR HSSVEQLLLF GRLLQRSTSL DWCFTHHPAA TGTFFSLMLL
GLKFCSCQKQ GNMHKFRHGL ELLEDRIYRA SLGWFSRQPE WYDVNIPNFC QSEAQSVSIF
AQYLLNERSD FSQSDSKEIA HENEKLAELI VWGKMDNYAV GKEKRKQLLL ILCQHESDRL
DVWAQPISSK DSPYSRLKVS SGKWTEHAKT AFLVDPRIAI SLVSRFLENI ALKSEVTQLV
EAHIVDLRTI PEALPYFLTS KTVEENSVLL QHLPHWAACS ITQALEFLTP NYKGHPRVMA
YVLRVLESHP PERVTFFMPQ LVQSLRYDEG RLVEGYLLRA AQRSDIFAHI LTWHLQGESF
QETVKDGAFD KNASFQASLA EVRQHIIDGF TLKALDLFNR EFDFFEKVTS ISGALFPLPK
EERRAGIRRE LEKIKIQGED LYLPTAPNKL VKGIQIDSGI PLQSAAKVPI MITFNVVDRD
GNHNDVKPQA CIFKVGDDCR QDVLALQVIS LLRDIFEAVG LNLYLFPYGV LPTGAGRGII
EVVPYTRSRS QMGESTDGGL YEIFQQEFGP VGSPSFETAR GNFLTSSAGY AVASLLLQPK
DRHNGNLLFD NIGRLVHIDF GFIFETSPGG NMRFESAHFK LSHEMTQLLD PSGDMKSETW
HQFVSLCVQG YLAARRYMEG IISTVEMMVE SGLPCFS
//
